Background Concerns have been raised recently regarding the efficacy and safety of Botulinum toxin type A (BTA) injections following COVID‐19 vaccination. Aims To assess the influence of BNT162b2 mRNA vaccine on the safety and efficacy of BTA injections performed for aesthetic indications. Methods A retrospective cohort study followed patients undergoing periodic BTA treatments who completed two doses of BNT162b2 vaccine. The latency between BTA injections before and after getting vaccinated was assessed for all study participants. Efficacy and longevity of BTA was reflected and evaluated by the latency between BTA injections. Patients were longitudinally monitored for the development of adverse events. Results Forty‐five patients were eligible for inclusion in the current study. The mean (standard deviation [SD]) age of patients was 48.3 (8.9) years and 40 (88.9%) patients were females. The mean (SD) number of pre‐ and post‐ COVID‐19 vaccination BTA injections was 5.1 (2.6) and 3.1 (0.4), respectively. The average (SD) interval between BTA injections after COVID‐19 vaccination (96.0 [12.3] days) was significantly shorter than before it (118.6 [22.7]; P<0.001). No severe BTA‐associated adverse events were registered after the administration of BNT162b2 vaccine. Conclusions Our findings indicate that BTA might be less effective after COVID‐19 vaccination. Further research is required to delineate the pathomechanism underlying this observation.

To the Editor, COVID-19 has affected the entire world since its onset in 2020.Recently, concerns have raised regarding potential hypersensitivity reactions of previously placed HA dermal fillers with COVID-19 vaccines. The Moderna mRNA-1273 vaccine trial reported an incidence rate of facial swelling of 0.02% after receiving the vaccine. 1 We conducted a retrospective study that aimed to assess the incidence of adverse events related to COVID-19 vaccines.All included patients had received two doses of Pfizer/BioNTech COVID-19 vaccine (US) (interval of 21-28 days) and had been previously injected with dermal fillers in the tear trough area, from January 2020 to January 2021. This study adhered to the principles

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