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Background Dermal filler injections continue to grow in popularity as a method of facial rejuvenation. With this increase in the number of injections, comes an increasing number of types of filler-related complications. Objective We report a series of cases where dermal filler injected in the face migrated to the orbit. Treatment methods and possible mechanisms of this newly reported complication are discussed. Methods A retrospective, multicenter analysis was performed on patients with dermal filler migration to the orbit after facial filler injections. Results Seven patients presented with orbital symptoms after filler injection and were subsequently found to have dermal filler in the orbit. There were six females and one male, with an age range of 42-67 years. Four out of seven patients underwent orbitotomy surgery, one patient underwent lacrimal surgery, one patient had strabismus surgery and one patient was treated with hyalurodinase injections. All patients have remained stable postoperatively. Conclusion Orbital complications secondary to migrated filler may occur long after the initial procedure. Since the site of the complication is distant from the injection site, patients and physicians may not immediately make the connection. Furthermore, this may lead to unnecessary examinations and a delay in diagnosis while looking for standard orbital masses. Thus, dermal fillers should be considered in the differential diagnosis of patients presenting with a new onset orbital masses.

In this pilot study a series of three separate triamcinolone fornix injections at 4-week intervals reduces the inflammatory effects of thyroid orbitopathy, as measured by clinical activity score. The treatment was simple, effective, and safe eliminating the side effects associated with systemic corticosteroid use.

ABSTRACT.Purpose: The purpose of this study was to evaluate the involvement of human papillomavirus in the pathogenesis of primary and recurrent pterygium in northern Israel. Methods: A retrospective study examined 100 randomly chosen pterygium specimens with solar elastosis, from 100 patients who underwent pterygium surgery during 2012-2013 at the Emek Medical Center. All the specimens were analysed for evidence of human papillomavirus infection by immunohistochemistry. Results: Human papillomavirus was not detected in any of the 100 pterygia samples by immunohistochemistry. These used samples were taken from 100 patients with mean age of 51.5 years and a primary: recurrent ratio of 8.09:1. Conclusion: We conclude from our study that human papillomavirus infection does not appear to be an important pathogenic factor of pterygium in Israel.

Background Concerns have been raised recently regarding the efficacy and safety of Botulinum toxin type A (BTA) injections following COVID‐19 vaccination. Aims To assess the influence of BNT162b2 mRNA vaccine on the safety and efficacy of BTA injections performed for aesthetic indications. Methods A retrospective cohort study followed patients undergoing periodic BTA treatments who completed two doses of BNT162b2 vaccine. The latency between BTA injections before and after getting vaccinated was assessed for all study participants. Efficacy and longevity of BTA was reflected and evaluated by the latency between BTA injections. Patients were longitudinally monitored for the development of adverse events. Results Forty‐five patients were eligible for inclusion in the current study. The mean (standard deviation [SD]) age of patients was 48.3 (8.9) years and 40 (88.9%) patients were females. The mean (SD) number of pre‐ and post‐ COVID‐19 vaccination BTA injections was 5.1 (2.6) and 3.1 (0.4), respectively. The average (SD) interval between BTA injections after COVID‐19 vaccination (96.0 [12.3] days) was significantly shorter than before it (118.6 [22.7]; P<0.001). No severe BTA‐associated adverse events were registered after the administration of BNT162b2 vaccine. Conclusions Our findings indicate that BTA might be less effective after COVID‐19 vaccination. Further research is required to delineate the pathomechanism underlying this observation.