Land cover change analyses are common and, especially in the absence of explanatory variables, they are mainly carried out by employing qualitative methods such as transition matrices or raster operations. These methods do not provide any estimation of the statistical significance of the changes, or the uncertainty of the model and data, and are usually limited in supporting explicit biological/ecological interpretation of the processes determining the changes. Here we show how the original nearest-neighbour contingency table, proposed by Dixon to evaluate spatial segregation, has been extended to the temporal domain to map the intensity, statistical significance and uncertainty of land cover changes. This index was then employed to quantify the changes in cork oak forest cover between 1998 and 2016 in the Sa Serra region of Sardinia (Italy). The method showed that most statistically significant cork oak losses were concentrated in the centre of Sa Serra and characterised by high intensity. A spatial binomial-logit generalised linear model estimated the probability of changes occurring in the area but not the type of change. We show how the spatio-temporal Dixon’s index can be an attractive alternative to other land cover change analysis methods, since it provides a robust statistical framework and facilitates direct biological/ecological interpretation.

Experimental studies in monkeys have demonstrated that injection of gamma-aminobutyric acid (GABA) agonists into the superior colliculus restricts saccadic eye movements, while injection of GABA antagonists leads to square-wave jerks (SWJ). To investigate the role of GABA in saccadic interruptions of fixation, we treated five patients who had SWJ and square-wave oscillations (SWO) with valproic acid (VPA) (2000 mg/d), which has been shown to increase brain GABA levels. VPA effectively reduced the SWJ/SWO in three patients, abolished them in one patient, but was ineffective in the fifth, who had a localized lesion in the cerebellar vermis. VPA effects may have been due to the restoration of the GABAergic tonic inhibitory action from the substantia nigra pars reticulata to the superior colliculus.

Infrared oculographic recordings of saccades evoked by auditory or visual targets in four patients with hemianopia due to an occipital lesion showed that these patients employed a different strategy to find visual and auditory targets in each hemifield. In the seeing hemifield, the patients acquired auditory targets with both monosaccadic and multiple saccadic refixations. The first saccade, the largest, brought the eyes toward the target; the following smaller saccades completed the search as in normal subjects. Saccades to visual targets consisted of one orthometric saccade or two saccades. By contrast, in the blind hemifield the patients acquired auditory targets by a staircase strategy consisting of stepwise saccadic search movements similar to those used for visual targets in the same hemifield. The similarity of strategy to auditory and visual targets suggests a common motor program controlled by the visual input. The latency, accuracy, and velocities of visual and acoustic responses were equal in both hemifields.