Das Phthalazin (I) kann mit Bromessigester (II) zum Phthalaziniumsalz (III) quaterniert werden.

Z ZFifteen new pyridazine and phthalazine derivatives were prepared (in good to excellent yields) and tested in vitro as antimicrobial compounds. All the compounds have proved to have a remarkable activity against Gram positive germs, the results on Sarciria Luteea being spectacular. Correlation structurebiological activity have been done. Stereo-and region-chemistry involved in these reactions are discussed.

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The regiochemistry of the [3+2] cycloaddition reactions between 4‐R‐phenacylpyridazinium ylides and acrylonitrile has been studied. Theoretical and experimental studies have been performed, both of which show that the reaction is regiospecific. Four new tetrahydropyrrolopyridazine heterocycles have been obtained. The structures of the new compounds were established by elemental (C,H,N) and spectral analyses (IR, 1H and 13C NMR, MS).