Background: Infertility is a global health issue affecting approximately 8-10% of couples and has multidimensional problem with social, economic and cultural implications, which can take threatening proportions in countries with strong demographic problems. Objective: To investigate the determinants of infertility among couples seeking treatment. Methodology: A cross sectional study was conducted in selected private clinic of Dhaka city among 196 infertile couple by face to face interview using pretested semi structured questionnaire. Results: The sample studied consisted of 196 infertile couple. One third (38%) aged 26-30 years, majority Muslims (96%), housewives (72%) and one fourth (24%) had education level of secondary to higher secondary. Slightly more than half of their family income was taka 5361-21270. More than three fourth (66%) had primary infertility. Concerning the determinants of infertility polycystic ovary, hormonal imbalance, and fallopian tube blockage was 19%, 16% and 7% respectively but unexplained factors (28%) crossed the other factors. Only male factor was 10% and combined male and female factors were 10% among study subjects. Regarding the daily habits of the male participants, 18% were smokers. Conclusions: The determinants of female infertility are problems in the fallopian tubes and the uterus, disorders of menstruation, sexual disorders, age and ovarian failure. Female infertility is a complex problem that should be considered carefully by the government and stakeholders in each country in order to find effective interventions and solutions.

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<p class="abstract"><strong>Background:</strong> Psoriasis is a chronic, inflammatory, systemic disease. In response to therapy in psoriasis patients, the psoriasis area severity index (PASI) is used to evaluate the disease activity. However more objective laboratory tools should be developed besides PASI. In various inflammatory diseases, mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), and platelet lymphocyte ratio (PLR) are inflammatory biomarkers that are known to be evaluated. The aim of the study was to assess the frequency of platelet activation and leukocyte infiltration by measuring MPV, NLR, and PLR.</p><p class="abstract"><strong>Methods:</strong> This was a case-control observational study conducted at department of dermatology and venereology at Bangabandhu Sheikh Mujib Medical University from July 2016 to December 2017. A total of 55 psoriasis cases and 55 healthy controls were included according to inclusion and exclusion criteria.<strong></strong></p><p class="abstract"><strong>Results:</strong> We have investigated a total of 55 psoriasis patients and another 55 age-sex matched control. There were 31 males (56.36%) and 24 females (43.44%) psoriasis patients in the study. The mean age of the patient was 34.27±13.44 years. Mean±standard deviation (SD) value of MPV, NLR, and PLR in our study cases were 9.92±1.21, 4.32±8.53, and 292.96±88.80 whereas in the case of control values were 9.46±0.636, 4.54±8.51, and 162.26±103.38 respectively.</p><p class="abstract"><strong>Conclusions:</strong> In conclusion, we suggest MPV is a strong indicator of psoriasis severity. MPV and PLR should be followed up routinely to take preventive measures against psoriasis-related micro and macro vascular thrombotic complications.</p>