The purpose of the work. Compare the effectiveness of PRP and general accepted methods of local therapy for long-term unhealed wounds in patients with diabetic foot syndrome.
Materials and methods. A study was performed in 33 long-term patients unhealed wounds on the foot and leg in the neuropathic form of diabetic foot syndrome. Patients were divided into two groups depending on the nature of the received therapies - PRP and local therapy according to generally accepted principles. The effectiveness of therapy was assessed by the nature of changes in the microflora and c wound cell composition, as well as wound surface area on the 1st day, 8th and 22nd after starting treatment.
Results. The use of PRP allowed to observe on the 8th day regenerative-inflammatory type of cytogram, have manifestations of vascularization and epithelialization, reduce the number of patients with infected wounds by 2.7 times and reducing the wound surface area by 1.7 cm, which is 3.4 times more than in the second group (0.5 cm). The introduction of the second dose of PRP is even more stimulating reparative changes in the wound, manifested by the regenerative type of cytogram, reducing the number of infected wounds by 8 times, and reducing the area wound surface 2 times from the first measurement, while in the second group only on the 22nd day there were positive changes that were characteristic of the first group on the 8th day.
Conclusion. Thus, the use of PRP in therapy is long unhealed wounds in diabetic foot syndrome, is a promising area of regenerative therapy. PRP is a way to obtain a natural concentration of internal factors of growth with minimal invasiveness and low costs. Proposed method of biological therapy in such patients is simple and affordable for both patient and for the doctor.
Objective. The aim of the study was to analyze the effectiveness of modern treatments in 485 patients with chronic hemorrhoids stage II-III-IV over the past 3 years.
Results. An individual-combined approach to the treatment of hemorrhoids has been introduced, as many patients can have nodules at different stages of the disease at the same time. Used a combination of methods with different ways to influence the pathogenesis of hemorrhoids. Thanks to the introduction of a set of systemic measures, good results were obtained, namely the healing time of postoperative wounds was reduced by 35-40% and the intensity of postoperative pain was reduced by 3-4 points on a 10-point analog visual scale.
Conclusions. The use of an individual integrated approach to each patient in choosing the tactics of surgical treatment of hemorrhoids and the widespread introduction of modern techniques, has reduced the duration of the postoperative period, preserve radical intervention and reduce the likelihood of recurrence.
Objective. The purpose of the study is to reveal the features of the course of the wound process in patients with acute paraproctitis against the background of diabetes.
Methods. An analysis of the results of treatment of acute parаproctitis against the background of diabetes in 328 patients over the past 5 years was carried out.
Results. It was found that these patients are define by extensive tissue damage in area and the predominance of gram-negative bacteria in mixed aerobic flora, the addition of anaerobic flora is the cause of the spread of the purulent process and deep destruction of tissues. The synergism of the aerobic-anaerobic flora in combination with the pathogenetic factors of diabetes contribute to a severe and prolonged course of the inflammatory process, as evidenced by the preservation of a high index of intoxication until the 14th day.
Conclusions. The criteria for choosing the method of operation are based on the localization of the abscess and the main purulent course, its relationship to the elements of the external anal sphincter, the nature of the scarring process in the area of internal diversion and the function of the closing apparatus of the rectum.