Objectives: Current weight estimation models do not consider the contribution of fetal soft tissue to fetal weight. We have investigated new weight estimation models that use a combination of conventional biometry and soft tissue parameters. Methods: A cross-sectional study of 248 fetuses was performed using 3DUS to acquire standard biometry (BPD, AC, FDL), fractional arm volume (Avol), and fractional thigh volume (TVol) within 4 days of delivery. Multiple linear regression was used to develop a 'modified Hadlock' model (BPD, AC, FDL) and similar models that also included soft tissue parameters for predicting birth weight (BW). New models were prospectively applied in 55 pregnancies. Predicted and observed weights were compared and signed percent differences calculated. Mean and SD of % differences were taken as measures of systematic and random prediction errors, respectively. Proportion of subjects with predicted BW within 5 or 10% (inclusive) were compared using McNemar's test. Results: For the validation group, the mean maternal age was 27 ± 7.0 (SD) years. Introduction: For successful reproductive outcome embryo quality and endometrial receptivity are essential requirements. The definition of the latter, however, has stirred some controversy and the reason for the low implantation rate remains as yet unclear. Although several studies on intrauterine and ovarian blood flow have been reported results have been at best conflicting. Methods: The prospective study was designed to investigate the role of VEGF-concentration in serum and follicular fluid and the role of 2D/3D (Doppler) sonography of the ovaries in predicting conception in an in-vitro fertilization-embryo transfer (IVF-ET) programme. Transvaginal 2D/3D (Doppler) sonography was performed in 102 patients on the day of oocyte retrieval. Primary outcome variable was the correlation between conception rate and sonographic as well as biochemical parameters. Results: As expected, significant correlation was found between ovarian volume, number of aspirated oocytes and serum estradiol concentration. In contrast, none of the sonographic parameters were correlated with reproductive outcome. Of note, VEGF concentration in serum but not in follicular fluid was significantly higher in conception than in non-conception cycles (p = 0.024). A serum VEGF cut-off level of 233 pg/ml is able to predict conception with a sensitivity of 65% and a specificity of 71%. Conclusion: In contrast to 2D/3D (Doppler) sonography serum VEGF levels may allow prediction of IVF success. Objectives: To evaluate three-dimensional (3D) ultrasound for verification of the position of micro-inserts after sterilization. Methods: Prospective study of 20 consecutive patients who had ESSURE devices inserted. All patients had an X-ray scan three months after insertion; if there was any doubt about position, hysterosalpingography was performed. 3D ultrasound by a different investigator preceded the radiography. OC107

A total of 602 organ systems in 260 exams out of 193 patients were identified for this study (26 exams in the first trimester, 161 in the second, and 73 in third trimester). Table 1 shows the total number of organs scanned with 3DUS for each impact group. In the D group, the most significant findings were in these organs: face exams 10, brain 5 and uterine shape 4. In the I group, the most significant findings were in these organs: extremities 16 exams, urogenital system 15, placenta 15 and brain 10. In the V group, the most significant findings were in these organs: face 101 exams, spine 75, extremities 74 and skull 68. In the S group, the most significant findings were in these organs: heart 5 exams, and adnexa 3.

Individuals with osteoporosis, i.e., low bone mass, are at enhanced risk for fracture, disability, and death. Hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer. Osteoporosis rates are predicted to increase due to an aging global population yet there are limited pharmacological treatment options for osteoporosis, particularly for long-term management of this chronic condition. Moreover, the drug development pipeline is relatively bereft of new strategies and drug candidates, creating an urgent need for developing new therapeutic strategies for treating osteoporosis. In this mini-review, we speculate about the potential for non-invasive soft tissue manipulation (STM) to exert anabolic effects on the skeleton that may provide therapeutic benefit for individuals with low bone mass. Our rationale is premised on work by us and others showing that STM leads to decreased levels of chemokines and pro-inflammatory cytokines (such as Interleukin (IL)-3, IL-6, and IL-8) known to restrict the differentiation and/or activity of bone-forming osteoblasts. However, there are no published studies examining whether STM impacts bone mass, potentially limiting the widespread use of this non-invasive and non-pharmacological intervention in the worldwide treatment of patients with osteoporosis, individuals with low bone mass due to being bed-ridden or otherwise mobility-limited, and persons subjected to spaceflight-related bone loss.

+1.4847 (AC 2) −26.0729 (AC) −0.2637 (AVol 2) +52.5110 (AVol) +269.

No abstract