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Neoplastic lesions of thyroid are common diseases that affect people all over the world. These lesions presents clinically in various forms having wide spectrum of presentation. Thyroid malignancies approximately are estimated to be constituting between 1-1.6% of all cancers, and thyroid tumours form around 90% to 93% among all malignancies of endocrine. Examination of these neoplastic thyroid lesions histopathologically form an important and confirmatory tool in the diagnosis of the neoplastic thyroid lesions. Materials and Methods: 75 cases of neoplastic thyroid lesions were studied and analysed, in the present study, this study was conducted in the Department of Pathology of an autonomous institute run by Government of Karnataka, RIMS, Raichur, India. The total study period was three (3) years. Out of these 3 years, retrospective study formed bulk of the study which was 2 years and prospective study was for a period of 1 year. The histopathologically diagnosed thyroid tumors were classified based on WHO classification of thyroid tumors. Results: After Histopathological diagnosis, Results were analysed, and showed that neoplastic lesions of thyroid constituted 75 cases, out of which, a total of 81.3% were diagnosed in females and 18.7% cases were diagnosed in males, and these lesions were predominantly seen in female patients giving a female: male ratio of 4.3:1. Study showed that the youngest patient was aged 12 years and the oldest patient was aged 65 years at the time of presentation, with a mean age of being 38.5 years. Follicular adenoma was diagnosed in 53.33% with 40 cases followed by malignant neoplastic thyroid tumour, papillary carcinoma accounting for 44.00% with 33 cases, other lesion that was diagnosed was follicular variant of papillary carcinoma in 2.67% 2 cases. Conclusion:The occurance of neoplastic diseases in thyroid nodules is of major health concern. Present study is done to know the statistical incidence of neoplastic thyroid lesions in this region and to evaluate and confirm the diagnosis histopathologically of these thyroid tumors and classify their subtypes in detail.