Purpose: The aim of this study is to evaluate oroantral communication (OAC) repair using one bone substitute (Fisiograft) and platelets rich fibrin (PRF). Patients and methods: In the present study, eight patients complaining from OAC following extraction of maxillary posterior tooth were selected. The bony defect of the OAC was grafted with Fisiograft sandwiched between two PRF membranes. Then the graft was covered by buccal advancement flap. The patients were followed up clinically after 1, 2, 4 and 12 weeks postoperatively. Radiographic evaluation was performed immediately and after twelve weeks postoperatively. Results: Successful closure of the OAC was achieved in all cases. None of the cases reported recurrence of the OAC or regurgitation of fluids from the nose. There were no signs of dehiscence, infection, allergic reaction, ulceration, or exposure of the material. The covering mucosa returned to the normal color and texture by the end of the first month. Radiographically, the bony defect appeared radiolucent immediate postoperatively. After three months, there was almost complete healing of the bony defect of the OAC. Densitometric measurements showed statistically significant increase in the bone density at the defect area after three months postoperatively. Linear measurements showed no statistically significant vertical loss of alveolar bone after three months postoperatively.