Amantadine (1-aminoadamantane hydrochloride) is effective in the prophylaxis and treatment of influenza A infection. In tissue culture this selective, strain-specific antiviral inhibits either the initiation of infection or virus assembly. The basis of these actions is similar and both the haemagglutinin and M2 proteins are implicated suggesting that amantadine interferes with their functions or the interactions between these two virus proteins. Mutations which confer resistance to amantadine are restricted to four amino acids within a hydrophobic sequence of M2 indicating that the primary target of drug action is the membrane-associated portion of this molecule.

A virus was isolated from a group of feedlot cattle with acute respiratory disease that was characterized by physicochemical methods as an adenovirus and identified serologically as a bovine adenovirus type 3. Intratracheal inoculation of three 4 month old colostrum deprived calves resulted in pyrexia, hyperpnea, dyspnea, anorexia and in one animal a mild diarrhea.

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