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Today, in Kharkiv region, most of the surface water bodies as a result of man-made and anthropogenic loading have lost their natural purity and the ability to self-purify. One of the features of water resources of the region is that the rivers, which serve as the main sources of water supply, are also used as receivers of treated wastewater. In order to analyze the state of pollution of the aquifer of Kharkiv region during 2007–2016, laboratory studies of water of surface water reservoirs of the 1st and 2nd categories were conducted and summarized. The researchers have found that over the past 10 years the pollution of surface water bodies of the 1st category according to sanitary-chemical indicators is at the level of 4.5%, microbiological indicators – 14%, water pollution of reservoirs of the 2nd category is 20% and 12%, respectively. In order to prevent the occurrence of diseases of different etiology among the population of Kharkiv region, the source of which is the water factor, a set of methodical and practical measures that will contribute to the improvement of the surface water of the region has been developed

The aim of the study was to study the effect of liposome emulsion with grape seed polyphenols (LEGSP) on the secretory and motor-evacuatory functions of the gastrointestinal tract and efficacy in experimental gastric ulcer. Materials and methods. The experiments were carried out on 36 white non-linear male rats weighing 180–220 g and 12 white non-linear mice weighing 18–20 g of different sexes. The effect of LEGSP on the secretion of gastric juice was assessed in terms of total, free and associated acidity of gastric contents; on the motor-evacuation function of the gastrointestinal tract – according to the percentage of intestinal length passed by the contrast mass from the absolute intestinal length. Evaluation of the antiulcer activity of the emulsion was carried out according to macroscopic indicators of the intensity of the formation of ulcerative defects in the gastric mucosa. Statistical processing of the results was carried out using parametric and nonparametric methods of analysis. Differences between the control and experimental groups were considered statistically significant at P < 0.05. Results. It was found that for 4 hours of the experiment under the influence of LEGSP the secretion of gastric juice decreased by 12.7 % relative to the group of intact animals. Total, free and associated acidity decreased by 33.3 %, 41.4 % and 24.2 %, respectively. That is, the use of LEGSP leads to a moderate suppression of the acid-producing function of the stomach. An increase in the motor function of the intestine was also observed with the introduction of LEGSP to mice, as evidenced by an increase in the relative index of the intestinal length passed by the contrast agent by 28.5 % compared with the intact control. In the experimental group, which received LEGSP, the average area of ​​erosive damage areas decreased by 3.7 times and amounted to (5.7 ± 0.5) mm2. The ulcerative index is 1.4; antiulcer activity – 93.4 %. Conclusions. A new herbal remedy based on grape seeds (LEGSP) leads to the suppression of the acid-producing function of the stomach, stimulates the motor-evacuation function of the intestine and has high antiulcer activity in the model of acute serotonin gastric ulcer.

In the general structure of joint diseases in terms of incidence, coxarthrosis ranks second after gonarthrosis and first in terms of the degree of disability. The development of this disease is accompanied by a persistent, severe pain syndrome, as well as functional disorders such as lameness, limited mobility, and then premature disability of patients. The main factors for the occurrence of coxarthrosis are congenital, but there are also internal factors that lead to a decrease in the resistance of the cartilage itself when performing standard loads (walking). To prevent exacerbations during the period of remission of coxarthrosis, physiotherapy exercises are prescribed to prevent exacerbations. The authors developed an optimal exercise therapy scheme for patients with coxarthrosis and compared the effectiveness of the therapy in patients treated with traditional physical therapy and an original set of physical exercises. This comparison showed that the values obtained when testing on a visual analogue scale (assessment of pain intensity) in all two analyzed samples correspond to the presence of severe pain in patients. As a result of the treatment, the indicator significantly (p<0.05) decreased by 58.6% in the experimental group and by 16.9% in the control group. The values of pain assessment according to the Lequesne index, noted by patients, also decreased in all two groups ‒ by 11.9% in the control group (p<0.05), by 46.3% in the experimental group (р<0.05). At the same time, according to the Harris test, the assessment of pain intensity in patients after treatment decreased approximately the same as in the control group (by 60.9%, p<0.05). The results of the study showed the best results in reducing pain, eliminating stiffness of movements and increasing the functionality of the musculoskeletal system. Keywords: coxarthrosis, physical therapy, joints, physiotherapy.

Introbuction: The scientific-methodical substantiation of measures on supplying the population with drinking water of guaranteed quality is one of the main factors of sanitary and epidemiological welfare of the population of the region. The aim: The aim of this work is the analysis of the state of nitrate pollution of sources of drinking water supply in Kharkiv region Materials and methods: Studies of drinking water were conducted and evaluated according to the requirements of current standards Results: In recent years in the area there has been a tendency of deterioration of the quality of drinking water from decentralized water supply facilities (wells and capping sources) Conclusions: The percentage of drinking water samples with exceeding the established standards on sanitary-chemical indicators of the objects of centralized water supply in recent years is on the average 15%, and it is 30% for the facilities of decentralized water supply.