Background. One of the major challenges of modern medicine is prevention and early detection of diseases, especially malignant tumors, since the stage does influence the prognosis and treatment costs. Thyroid involvement is currently one of the leading endocrine disorders in terms of overall morbidity and prevalence in the world. Thyroid cancer is one of the localizations, which being timely detected and properly treated, has a favorable prognosis, when 20–30-year survival rate exceeds 90 %. Therefore, the search for simple, minimally invasive, but highly informative techniques for optimizing the algorithms for diagnosis, differential diagnosis and monitoring of this disease remains a priority. Purpose – to determine and substantiate the diagnostic value of comprehensive assessment of the thyroid status and full blood count values in patients with thyroid nodules. Materials and methods. The study involved 60 patients with thyroid nodules, which according to ultrasonography (US) of the thyroid were classified as TR-4 category of thyroid nodules, TIRADS scale (4–6 points, suspected malignant thyroid changes). The examination included the following: questionnaire, ultrasound examination with fine-needle aspiration puncture biopsy, cytological examination, counting the thyroid hormone concentration, full blood count. The study was carried out at the premises of State Institution “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”. Results. Assessment of thyroid status of patients with thyroid nodules showed a significant correlation between the severity of thyroid malignancy and TSH levels (according to Kruskal – Wallis test, H = 7.30, p < 0.05), FT4 (H = 17.64, p < 0.001) and FT3 (H = 12.41, p < 0.01). Patients of Group I with benign thyroid process showed significant (p < 0.05) decrease in total hemoglobin along with significantly frequent (p < 0.05) microcytic anemia. According to the studies, Group II had a significant (p < 0.05) decrease in total platelet count and plateletcrit, as well as an increased average platelet volume and the percentage of large platelets compared to Group I. The blood values in malignant thyroid process (Group III) are characterized by increased levels of leukocytes and the proportion of eosinophils and basophils in the leukocyte formula compared to Group II (p < 0.05). Conclusions. The outcomes of comprehensive assessment of thyroid status and full blood count values in patients with thyroid nodules can be used in preoperative diagnosis as a differential prognostic tool to assess their malignant potential.

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Today, in Kharkiv region, most of the surface water bodies as a result of man-made and anthropogenic loading have lost their natural purity and the ability to self-purify. One of the features of water resources of the region is that the rivers, which serve as the main sources of water supply, are also used as receivers of treated wastewater. In order to analyze the state of pollution of the aquifer of Kharkiv region during 2007–2016, laboratory studies of water of surface water reservoirs of the 1st and 2nd categories were conducted and summarized. The researchers have found that over the past 10 years the pollution of surface water bodies of the 1st category according to sanitary-chemical indicators is at the level of 4.5%, microbiological indicators – 14%, water pollution of reservoirs of the 2nd category is 20% and 12%, respectively. In order to prevent the occurrence of diseases of different etiology among the population of Kharkiv region, the source of which is the water factor, a set of methodical and practical measures that will contribute to the improvement of the surface water of the region has been developed