Background: Helicobacter pylori (H. pylori) proved to be highly prevalent all over the world. H. pylori may modify the absorption of many nutrients. Studies have suggested that, beyond iron, H. pylori infection may affect the homeostasis of other micronutrients such as vitamins and trace elements. Our study's aim was to assess the effect of H. pylori infection on some blood micronutrient level including zinc, selenium, vitamin C, and vitamin B 12 in children with chronic or recurrent unexplained dyspeptic symptoms and/or non-variceal hematemesis. Results: A cross-sectional case-control study was carried out in 32 children (4-18 years) with chronic or recurrent unexplained dyspeptic symptoms and/or non-variceal hematemesis. Patients were divided according to the results histopathology and rapid urease test into two groups, H. pylori-positive patients (18 patients) and H. pylori-negative patients (14 patients). Another control group of 18 children was included. Serum levels of zinc, selenium, vitamin C, and vitamin B 12 were measured in all children. Prevalence of H. pylori infection was 56.2%. The mean serum zinc levels were significantly lower in H. pylori-positive cases than in control group (84.2 ± 13.85 versus 94.6 ± 6.52 with P = 0.009) and lower than in H. pylori-negative cases but not statistically significant (84.2 ± 13.85 versus 92.2 ± 8.53 with P = 0.054). The mean serum vitamin C levels were significantly lower in H. pylori-positive cases than in negative cases and control group (220.7 ± 46.16 versus 305.1 ± 28.83 and 313.1 ± 31.43 with P < 0.0001). The mean serum vitamin B 12 levels were significantly lower in H. pylori-positive cases than in negative cases and control group (167.8 ± 76.98 versus 290.1 ± 69.92 and 326.1 ± 38.67 with P < 0.0001). The mean serum selenium level was slightly higher in H. pylori-positive patients than in H. pylori-negative patients and control group but not statistically significant (118.2 ± 11.13 versus 112.1 ± 8.69 and 113.1 ± 13.76 with P = 0.096, 0.243 respectively). Conclusion: Helicobacter pylori infection in children has a significant negative effect on the serum levels of zinc, vitamin C, and vitamin B 12 .

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Compression (or crushing) is used to induce nerve injury in test rats to study nerve degeneration and regeneration. The compression forces could be applied using a variety of techniques developed by several investigators. The lack of precise control of the applied compression may be the source of significant variations among observations. In this study, a Mosquito and dressing forceps were used. The Mosquito forceps was calibrated to determine the tip load corresponding to the clamping position. The dressing forceps was modified, instrumented with strain gauges and calibrated to directly measure the force applied at its tip. These two forceps were used to induce known and controlled nerve compression in 75 male Wistar rats (280-300g). The applied forces were of the order of 40N and 20N, for the Mosquito and dressing forceps, respectively.

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