Introduction. Using cytochemical methods, the activity of myeloperoxidase (MPO), as well as the content of cationic proteins, glycogen and lipids in the blood neutrophils of pregnant women with diffuse toxic goiter (DTG) was studied in a comparative aspect.Goal. To study the dynamics of changes in the cytochemical parameters of neutrophils in women's blood during physiological pregnancy, as well as in pregnant patients with DTG.Material and methods. The study included 82 pregnant women aged 20-40 years old with Hashimoto's thyroiditis and graves' disease. The subject of the study was the determination of immunological indicators: the level of autoantibodies to TSH, TPO and TG; the content of populations and subpopulations of lymphocytes, and cytochemical indicators of blood: MPO activity; cationic protein content; glycogen content; lipid content. Results. The activity of MPO in the blood neutrophils of women with a physiological course of pregnancy (comparison group) is similar to that in the control group. In the first trimester of pregnancy, the percentage of neutrophils with a moderate to high content of colored granules tends to decrease, which is reflected in the value of the average cytochemical index.Conclusion. It should be noted that significant shifts in the content of components of the phagocytic defense system were found in the blood neutrophils of pregnant women with thyrotoxicosis syndrome.

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16.12.2015) проведено исследование по определению его возможностей при установлении функциональ-ного состояния щитовидной железы (ЩЖ). Уста-новлено что активность фермента определятся в фолликулярных тиреоцитах и существенно меняется при различных патологических состо-яниях органа. В частности, в гистохимических препаратах ЩЖ больных диффузным токсическим зобом активность ТПО в стенке фолликулов и ме-жфолликулярных аденоматозных очагах высокая. Характерно наличие эпителиальных выпячиваний с выраженной активностью в периферических тиреоцитах. При заболеваниях ЩЖ в стадии эу-тиреоза активность фермента в фолликулярных тироцитах умеренная. Содержание фермента существенно снижено при макро-и микрофолли-кулярном коллоидном зобе и аутоиммунном ти-реоидите в стадии гипотиреоза. Делается вывод, что результаты предлагаемого гистохимического метода определения активности ТПО позволяют дополнить морфологическое заключение патоло-гоанатомов функциональным. Ключевые слова: щитовидная железа, ги-стохимия, тиреопероксидазаDeveloped at the Department of Histology DSMU histochemical method of detecting activity thyroperoxidase (TPO) (invention, foreground number 2015054203 from 16.12.2015) conducted a study to determine its capabilities when establishing a functional state of the thyroid gland (TG). It was found that the enzyme activity was determined in the follicular thyrocytes and varies considerably in various pathological conditions the organ. In particular, in histochemical preparations thyroid patients with diffuse toxic goiter TPO activity in the wall of the follicles and foci of adenomatous interfollicular high. It is characterized by epithelialprotrusion with marked activity in peripheral thyrocytes. In diseases of the thyroid gland in the stage euthyrosis enzyme activity in follicular thyrocytes moderate. The content of the enzyme significantly reduced by the macro and micro follicular colloid goiter and autoimmune thyroiditis in the stage of hypothyroidism was determined. It is concluded that the results of the proposed histochemical method for determining the activity of TPO allow pathologists to complement morphological conclusion functional.