Among the factors that can affect the glass surface chemical durability, pH, salts concentration, complexion agents presence, etc., the vial under filling is rarely considered. United States Pharmacopeia (USP) <660> test for glass surface chemical durability, prescribes a filling volume of 90% of glass containers brimful capacity but most of glass containers for inject able solutions are filled less than or by far less than 90%. Any time the filling volume is lower than the container nominal one, glass surface attack can be enhanced due to the increasing unfavourable surface/volume ratio. No regulation there is on this topic neither in the European Pharmacopeia nor in the United States Pharmacopeia.