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Experimentally induced hypoglycemia, using insulin as the hypoglycemic agent, was carried out, using three groups of guinea pigs. The differentiating factor was the time sequence. After the animals had been hypoglycemic for periods of time ranging from one to three hours, the cochlear endolymph. was collected and the sodium and potassium measured. It was found that there was a change in potassium/sodium ratio in the endolymph with the potassium concentration falling, and the sodium concentration rising. The magnitude of the change was quite time‐dependent with the most marked changes occurring after the longest period of hypoglycemia. The results point to the fact that the high potassium/sodium ratio is maintained by an active transport process which ultimately utilizes glucose as an energy source.

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