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Purpose: To enhance and control the release of ibuprofen from poly (D,L-lactide-co-glycolide)

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The study was undertaken to formulate and evaluate PEGylated-mucin matrices-based solid microparticles for oral administration of metformin hydrochloride (MTH). PEGylated-mucin matrices formulated with PEG-2000 and Mucin were used to prepare metformin-loaded PEGylated-mucin using solvent interaction method. Characterizations based on size and morphology, zeta potential and polydispersity index, loading and encapsulation efficiency (EE%) were carried out on the PEGylated matrices. In vitro release of metformin from the preparation was performed in phosphate buffer while in vivo release as a function of the antidiabetes effects were conducted in alloxan induced diabetes rats. Maximum and minimum EE% of 81.0 and 44.0% were obtained for matrices formed with PEG-Mucin ratio of 3:1(D) and 0:1(B), respectively. Irregular and rough matrices of size range 58.80 ± 0.21 µm to 124.1 ± 0.1 µm were produced. The release of MTH in phosphate buffer varied widely with the PEG and Mucin contents. Moreover, significant (p<0.005) amount of MTH was released in vivo from the matrices as demonstrated in the basal glucose reduction than the positive control. These results demonstrated that PEGylated matrices would likely to offer a reliable means of delivering metformin orally.