&lt;i&gt;In vitro&lt;/i&gt; Evaluation of PEGylated-Mucin Matrix as Carrier for Oral Delivery of Metformin Hydrochloride

Momoh, Mumuni A.; Adedokun, M. O.; Adikwu, M. U.; Ibezim, CE

doi:10.4314/tjpr.v13i7.5

Cited by 10 publications

(18 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…may limit its use; moreover chronic administration may cause hyperlactatemia, due to drug accumulation, with resultant lactic acidosis (Page, 2011). The poor bioavailability and short half-life of this drug (Dunn and Peters, 1995;Scheen, 1996), make the development of extended-release formulations desirable, in order to improve patient compliance and reduce the dosing frequency, resulting in better glycemic control and less side effects appearance (Di Colo et al, 2002;Hu et al, 2006;Corti et al, 2007Corti et al, , 2008; Momoh et al, 2013Momoh et al, , 2014Nayak et al, 2013;Li et al, 2014;Kim and Park, 2015).…”

Section: Introductionmentioning

confidence: 99%

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Maestrelli

Mura

González-Rodrı́guez

et al. 2017

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Maestrelli

Mura

González-Rodrı́guez

et al. 2017

International Journal of Pharmaceutics

View full text Add to dashboard Cite

“…At the end of this section, it should be poinetd out that the developed DDS has slow drug release profile in comparision with some reported doucuments . In the case of drug loading eficincy (EE), the fabracted nanosystm exhibited excellent quntity than those of the some othet reported DDSs for the delivery of the MET …”

Section: Resultsmentioning

confidence: 78%

A de novo formulation of metformin using chitosan‐based nanomicelles for potential diabetes therapy

Abbasian

Bighlari

Mahmoodzadeh

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

A de novo formulation of metformin (MET) was developed through the physical loading of drug into a chitosan-grafted-[poly(acryl amide)-block-poly(acrylic acid)] [CS-g-(PAAm-b-PAA)] terpolymer. For this purpose, CS was functionazed with phthalic anhydride followed by 4-cyano, 4-[(phenylcarbothioyl)sulfanyl]pentanoic acid to produc a macro-RAFT agent (CS-CTA). Afterward, acryl amide and acrylic acid monomers were graft and block copolymerized onto the synthesized CS-CTA through a reversible addition-fragmentation chain transfer (RAFT) polymerization technique to afford CS-g-PAAm copolymer and CS-g-(PAAm-b-PAA) terpolymer, respectively. The fabricated CS-g-(PAAm-b-PAA) terpolymer was loaded with MET as an anti-diabetic drug, and its drug release behavior was evaluated in the body simulated environment. As results, it was concluded that the fabricated CS-g-(PAAm-b-PAA) nanosystem has high potential as de novo drug delivery system (DDS) for diabetes therapy, mainly due to controlled drug release profile in comparison with conventional formulations of MET.

show abstract

“…The morphologies of the MPs were studied by scanning electron microscope (SEM). Several studies have demonstrated that the morphology and pore size of matrixes intended for drug delivery play an important role in the control of the release kinetics [11]. SEM images of batches A1 and A2 revealed small nonspherical particles that clumped together and mixed with little needle-like crystals (Figure 2).…”

Section: Morphology and Particle Size Of Insulin-loaded Mpsmentioning

confidence: 99%

“…Such delivery systems confer significant advantages, particularly for drugs that are unstable in the GIT. In this context, we recently developed a polyethylene glycol (PEG)/mucin system for oral delivery of metformin hydrochloride, where PEG acts as an adhesion enhancer [11]. Regarding the other component of this system, mucins are a family of high-molecular-weight glycosylated proteins produced by epithelial tissues in most animals, being the major structure-forming component of the viscoelastic mucus [12,13].…”

Section: Introductionmentioning

confidence: 99%

Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment

et al. 2020

View full text Add to dashboard Cite

In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.

show abstract

<i>In vitro</i> Evaluation of PEGylated-Mucin Matrix as Carrier for Oral Delivery of Metformin Hydrochloride

Cited by 10 publications

References 10 publications

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for oral therapy of type 2 diabetes mellitus

A de novo formulation of metformin using chitosan‐based nanomicelles for potential diabetes therapy

Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment

Contact Info

Product

Resources

About