mido derivative of sulfaquinoxaline,2 3[2-(4homosulfanilamido)-quinoxaline], was carried out./VN*J H This compound was synthesized by condensing N4-phthaloyl-4-homosulfanilyl chloride8 with 2-aminoquinoxaline2 and hydrolyzing the resulting product.The pharmacological activity of the product was kindly tested by D. Smith and O. Graessle of the Merck Institute. It was found to possess no bacteriostatic activity against E. coli, S. aureus, Cl.Welchii and D. pneumoniae Types I and II in vitro at concentrations in which marfanil was effective and did not prevent deaths due to D. pneumoniae Type I in the mouse when administered subcutaneously or intravenously in doses at which marfanil was slightly active.Departments of Botany and Biochemistry .
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