Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione], was extracted form turmeric and also synthesized by the condensation of vanillin substituted by acetyl acetone. Its metal complexes (M = Eu, Ce, La, Y, Cr, Pd) were prepared and characterized by IR and UV-vis spectroscopy. The result shows that curcumin coordinates with metal ions in bidentate mode in deprotonated form. Anti-bacterial study of the synthesized complexes indicated that this complexes has anti-bacterial activity against Klebsiella pneumonia and Escherichia coli. The result of agarose gel electrophoresis suggested that the complexes had good interaction with genomic DNA.

lid and delivery tube. Leach in 5 ml. of 50% nitric acid (v./v.) at about 80°C . for 30 minutes with frequent stirring. Add 5 ml. of 20% nitric acid (v./v.), filter, wash well with 1% nitric acid (v./v.), and reserve the filtrate. Dry

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The transition metal complexes [Cr(acac) 2 were synthesized from 1, 10-phenanthroline-5, 6-dione (phendione). The phendione ligands and its metal complexes were characterized by FTIR, UV-Visible spectroscopy, PL study and in some cases by GC-MS. The red emission band of complex [Zn(acac) 2 (phendione)] was observed by excitation at 250 nm. DNA binding activities of the complexes were studied by DNA Gel Electrophoresis. DNA binding studies of the synthesized compounds showed that the metal complexes are strong DNA binding and cleaving agents. The [Ni(phendione) 2 ] (ClO 4 ) 2 complex was the most effective DNA binding and cleaving agent and [Cr(acac) 2 (phendione)]Cl complex shows relatively lower affinity to the DNA. The metal complexes easily cause DNA degradation or cleavage (after 2.5 h) with genomic DNA rather than plasmid DNA. Antimicrobial activity studies revealed that all metal complexes of phendione showed efficient resistance to bacteria. The [Cr(acac) 2 (phendione)]Cl complex showed most potential antimicrobial activities against the bacteria Escherichia coli with an annular radius of the inhibitory zone, 4.33.

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