Abstract. For almost 10 years the KTB superdeep drilling project has offered an excellent field laboratory for adapting seismic techniques to crystalline environments and for testing new ideas for interpreting seismic reflections in terms of lithological or textural properties of metamorphic rock units. The seismic investigations culminated in a threedimensional (3-D) reflection survey on a 19 x 19 km area with the drill site at its center. Interpretation of these data resulted in a detailed, structural model of the German Continental Deep Drilling Program (KTB) location with dominant, steep faults in the upper crust. The 3-D reflection survey was part of a suite of seismic experiments, ranging from wide-angle reflection and refraction profiles to standard vertical seismic profiles (VSP) and more sophisticated surface-to-borehole observations. It was predicted that the drill bit would meet the most prominent, steeply dipping, crustal reflector at a depth of about 6500-7000 m, and indeed, the borehole penetrated a major fault zone in the depth interval between 6850 and 7300 m. This reflector offered the rare opportunity to relate logging results, reflective properties, and geology to observed and modeled data. PostVariscan thrusting caused cataclastic deformation, with partial, strong alterations within a steeply dipping reverse fault zone. This process generated impedance contrasts within the fault zone on a lateral scale large enough to cause seismic reflections. This was confirmed by borehole measurements along the whole 9.1 km deep KTB profile. The strongest, reflected signals originated from fluid-filled fractures and cataclastic fracture zones rather than from lithological boundaries (i.e., first-order discontinuities between different rock types) or from texture-and/or foliation-induced anisotropy. During the interpretation of seismic data at KTB several lessons were learned: Conventional processing of twodimensional (2-D) reflection data from a presite survey showed predominantly subhorizontal layering in the upper crust with reflectivity striking in the Variscan direction. Drilling, however, revealed that all rock units are steeply dipping. This confirms that surface common depth point (CDP) seismics strongly enhances subhorizontal reflectivity and may thus produce a very misleading crustal image. Although this was shown for synthetic examples earlier, the KTB provides the experimental proof of how crucial this insight can be.

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We reviewed our experience with six T-cell-rich B-cell lymphomas (TRBL) presenting in skin. Immunohistochemical studies were performed on all biopsies. The lymphoid population consisted mainly of CD3 and/or UCHL-1 (CD45RO) positive T cells. 5 to 15% of the lymphoid cells stained for the B-cell marker L26 (CD20). Monoclonality of the B-cell component was demonstrated in all cases, utilizing either light chain restriction (5 cases) or clonal immunoglobulin heavy chain gene rearrangement by polymerase chain reaction (PCR) (2 cases). One case was confirmed to be monoclonal by both techniques. Additionally, no clonal rearrangements of the T-cell receptor gamma gene were observed. There was considerable morphological variety in these cases. In H&E stained sections, the differential diagnosis included pseudolymphoma, peripheral T-cell lymphoma, Hodgkin's disease, Lennert's lymphoma and a MALT lymphoma. A significant component of monoclonal plasma cells was present in 3 of 6 cases, suggesting a possible origin from cutaneous immunocytoma. In fact, one of our cases was a biphasic lymphoma displaying TRBL with a small focus of immunocytoma. We conclude that immunophenotypic analysis is necessary for the diagnosis of TRBL. Pathologists should be aware of this type of cutaneous B-cell lymphoma to avoid misinterpretation as a pseudolymphoma.

Twelve patients with large plaque parapsoriasis (LPP) were investigated for the presence of predominant T-cell clones, analyzing the T-cell receptor (TCR) gamma-chain gene. The diagnostic and prognostic significance of TCR gene rearrangement status was assessed by a correlation with the long-term clinical follow-up. Six out of 12 patients showed a clonal T-cell population. Clinically, among the patients with clonal disease one developed clearcut mycosis fungoides (MF) after a follow-up of 8 years, in the other 5 patients no such diagnosis could be made after follow-up of 2-21 years (median: 9 years). In patients with polyclonal infiltrates the lesions remained virtually unchanged. These findings indicate that in LPP TCR gene rearrangement status has no prognostic significance and does not allow distinction of LPP and early MF. Both conditions show a clonal T-cell infiltrate with similar frequency, are very similar in clinical and histologic presentation and according to recent studies share the same low risk to develop overt MF. Therefore both terms refer to the identical clinical situation. This should be designated as early MF and efforts should concentrate on identifying those patients that are at risk to develop aggressive disease.

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