Clinical and endoscopic results of a study at 94 patients with gastroesophageal reflux disease (GERD) and obesity, as well as 85 patients with GERD are presented. A high incidence of atypical clinical manifestations of GERD on the background of obesity (an extraesophageal form of the disease) was revealed. An endoscopic study has mainly established reflux esophagitis of grades B and C (LA) in patients with obesity and a high percentage of cases (up to 59.5%) of duodenogastric reflux with a combination of GERD and obesity, especially in patients with atypical clinical form of reflux disease.

Резюме. Мета дослідження: визначити особливості добового рН-моніторингу стравоходу залежно відклінічної форми гастроезофагеальної рефлюксної хвороби у хворих на цукровий діабет (ЦД) 2-го типу. Матеріали та методи. Обстежені 82 хворі на ЦД 2-го типу з гастроезофагеальною рефлюксною хворобою. Всім хворим проведено добовий рН-моніторинг. Результати. Загальний відсоток часу, протягом якого рН у стравоході становив < 4, майже в однаковому ступені перевищував такий показник у контрольній групі (31,7 ± 2,3 % у хворих зі стравохідною формою гастроезофагеальної рефлюксної хвороби та 32,7 ± 2,9 % у хворих із позастравохідною формою проти 4,5 ± 0,3 % у контрольній групі, р < 0,01). Висновки. У хворих на ЦД 2-го типу зі стравохідною формою гастроезофагеальної рефлюксної хвороби при добовому рНмоніторингу рН < 4 у стравоході частіше відмічається при вертикальному положенні, а у хворих із позастравохідною формою - при горизонтальному. У хворих на ЦД 2-го типу зі стравохідною формою гастроезофагеальної рефлюксної хвороби порушення стравохідного рН асоціюється з кандидозним езофагітом, тоді як у хворих із позастравохідною формою - із дуоденогастральним рефлюксом

Changes in prostaglandin levels in the blood serum of patients with gastroesophageal reflux disease on the background of type 2 diabetes mellitus

No abstract

The aim: To study of changes in the level of serum gastrin (GN) and somatostatin (SST) in patients with GERD after ChECT and determined their characteristics from clinical forms of GERD. Materials and methods: 64 patients with different clinical forms of GERD were examined. The patients with GERD were divide into 2 clinical groups. Group 1 included 34 patients with GERD after ChECT, among them there were 14 males (41.2 %) and 20 females (58.8 %), with the average age of 40.2 ± 3.2 years. Group 2 consisted of 30 patients with GERD without ChECT. Among them there were 18 males (60.0 %) and 12 females (40.0%), with the average age of 38.9 ± 4.7 years. All patients were tested for serum SST and GN level by enzyme-linked immunosorbent assay (ELISA). Results: In all patients with GERD of both group there was a significant increase in the level of serum SST. At the same time, a more higher indicators have been established in 2 Group of patients (increase up to 0.702 ± 0.029 pg / ml – p <0.01). Noteworthy is the change in the level of SST in the serum in both groups of the examined patients depending on the clinical form of GERD, with the maximum increase in patients with atypical manifestation of GERD. The analysis of the level of GN in blood serum indicates its decrease in the examined patients. In this case, the most pronounced changes were found in patients with extraesophageal clinical signs of GERD. Conclusions: 1. In patients after ChECT gastroesophageal reflux disease often has atypical symptoms (mostly cardiac and bronchopulmonary forms in 45.0% and 25.0 % of examend patients). 2. There was detected an increase in the level of blood SST of patients with GERD while there was observed a decrease in the GN indicator in the serum, especially in its atypical forms. 3. Duodenogastric reflux is often diagnosed during endoscopic examination of patients with GERD after cholecystectomy. At the same time, its severity correlates with the level of SST in blood serum (r=0.76; p<0.01 in the typical form and r= 0.72; p<0.05 in the atypical clinical form of GERD).