The use of drug powders containing micronized drug particles has been increasing in several pharmaceutical dosage forms to overcome the dissolution and bioavailability problems. Most of the newly developed drugs are poorly water soluble which limits dissolution rate and bioavailability. The dissolution rate can be enhanced by micronization of the drug particles. The properties of the micronized drug substance such as particle size, size distribution, shape, surface properties, and agglomeration behaviour and powder flow are affected by the type of micronization technique used. Mechanical communition, spray drying and supercritical fluid (SCF) technology are the most commonly employed techniques for production of micronized drug particles but the characteristics of the resulting drug product cannot be controlled using these techniques. Hence, a newer technique called in situ micronization is developed in order to overcome the limitations associated with the other techniques. This review summarizes the existing knowledge on in situ micronization techniques. The properties of the resulting drug substance obtained by in situ micronization were also compared.

The solid form of atorvastatin liquid SMEDDS had been formulated successfully with enhanced shelf life and solubility.

Discovered in the 1920s, the biguanide metformin hydrochloride is still the first line drug in the management of Type 2 diabetes mellitus. Metformin hydrochloride is absorbed slowly and incompletely from the gastrointestinal tract. The present research work was undertaken with the aim of developing a fast dissolving film of metformin hydrochloride, suitable for oral trans mucosal administration. Fast dissolving films allow rapid drug dissolution in the oral cavity, ensuring bypass of first pass metabolism resulting in rapid absorption. Films of metformin were prepared by solvent casting method using Hydroxypropyl methylcellulose K15 (HPMC). Six formulations (F1-F6) of metformin hydrochloride were prepared and evaluated for their physical characteristics such as tackiness, thickness, tensile strength, elongation, weight variation, folding endurance, drug content and surface pH. The compatibility of the drug with HPMC was confirmed by FTIR studies. The formulations were subjected to disintegration, in-vitro drug release and the optimised formulation was evaluated for pharmacodynamic studies in diabetic rats. Among the formulations (F1-F6) F4 was found to be the best formulation which contained Hydroxypropyl methyl cellulose K15 at weight ratios of 1:4 and showed excellent film forming characteristics such as disintegration time at 42 sec and percentage drug release of 94.2% within 5 minutes. Pharmacodynamic assessment in diabetes induced rats demonstrated that the fast dissolving films of metformin had a quicker onset of action compared to conventional formulation.

It should be noticed that there is no drugs is available to treat lice and dandruff both are very great public health concern. So it is necessary to screen a drug especially of herbal origin to treat the both head lice and dandruff without affecting eyes. In the present study, Datura metel leaf extracts was evaluated for their insecticidal properties using head lice as an insect model. The study was conducted from November 2019 to March 2020. Plant sample (leaf) of Datura metel was collected from anantapur, Andhra Pradesh, India in November 2019. The various concentration of ethanolic extract of leaves of Datura metel was prepared by using distilled water. 20%, 40%, 60% were used. A colony of P.humanus capitis was collected by combing the hair of 20-25 infected children at the age group of 10-15. Head lice were reared in the glass vessels covered with nylon mesh containing tufts of hairs. The hair tufts was impregnated with appropriate doses for the screening. Pure culture of M.furfur (MTCC: 1374) was obtained from institute of Microbial type of culture collection, Chandigarh, India. The culture was maintained in SDA medium. The current study afford scientific basis for the ethnomedical use of this plant as antilice application. It is concluded that it can be optimistic that the present work proved Datura metel of dual therapeutic advantage to be a potential phytochemical target in the design of a drug for the treatment of both lice and dandruff.

The leaves of Ocimum kilimandscharicum (privately known as Kapura Tulasi) have for some time been being used in the indian arrangement of medication for its enemy of diabetic properies.Could be a short herb, nearby to india it is used to treat various afflictions checking colds, hacks,stomach torments,measles and the runs.ocimum kilimandscharicum, has a spot to family lamiaceae .The current work , meant to assess in vitro enemy of diabetic action. Against diabetic appraisal was done by the boundaries, for example, glucose take-up by yeast cells, estimation of hemoglobin glycosylation, extricate impact at physiological glucose fixation. The standard medication utilized was Metronidazole and gallic corrosive. It indicated that EEOK in portion of 250µg/ml demonstrated high level of glucose take-up and hindered the hemoglobin glycosylation by expanding the grouping of hemoglobin. It additionally showed the hindrance of hemoglobin glycosylation at various physiological convergences of the glucose where the concentrate diminishes the development of the glucose-hemoglobin complex and in this manner measure of free hemoglobin increments. In view of the outcomes, it has been demonstrated that the EEOK displayed hostile to diabetic movement.