Objectives: to evaluate the parents' knowledge of vaso-occlusive crises, to identify their attitudes and practices. Method: a retrospective, transversal, descriptive and analytical study carried out between January and June 2016 at the HUC of Brazzaville. The parents of sickle cell children aged 2 to 17 years, followed for at least one year, were interviewed. Results: a total of 319 parents were interviewed, including 221 women (69.3%) and 98 men (30.7%) with a mean age of 40.8 ± 9 years. They were unschooled 65 cases (20.4%), had primary education 41 cases (12.9%), secondary 149 cases (46.7%) and higher level 64 cases (20.1%). They had one child sickle cell 258 cases (80.9%). They knew sickle cell disease 283 cases (88.7%), its genetic transmission 249 cases (78.1%). The source of information was a health worker 211 cases (66.1%). They had a good knowledge of the vaso-occlusive crisis 101 cases (31.7%). In a vaso-occlusive crisis, they used a health facility 207 cases (64.8%), self-medicated 66 cases (20.7%). Their home practices were good 99 cases (31%), fairly good 135 cases (42.3%) and bad 85 cases (26.5%). Parents aged 25 to 34 (OR = 1.8 95% 1 -3), secondary (OR = 1.7 95% 1 -2.7) and with good practices (OR = 4.5 95% 2.7 -7.5) are those who have a good knowledge of vaso-occlusive crises. Conclusion: The importance and severity of vaso-occlusive crises in the sickle-cell child's life experience, the crucial role played by parents in their care requires that the information, education and communication of these children be strengthened To improve their quality of life.