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Of the pharmaceutical preparations at present in use for the pharmacological control of fertility, those designed according to Pincus' prototype have been the objects of by far the widest experience and are unsurpassed for contraceptive reliability and regularity of cycles. Their mechanism of action will, therefore, constitute the primary topic of this discussion. The conclusions reached will mutatis mutandis be applied to other forms of oral contraception. The so-called Pincus-pill, as is well-known, consists of an estrogenic and a progestational substance and is given for 20 to 22 days during each (artificial) menstrual cycle. Several dozen brands of the combination-pill are now available. They differ mainly in the nature and quantity of the progestational compound, not so much in their estrogen-content, since only two estrogenic substances are used, viz. ethynyl estradiol and mestranol (Fig. I), the 17a-Athinylostradiol 17a-~thinylSstradiol-3-methylither EE (ethinyl estradiol) EE3ME (ethinyl estradiol-3-methylether) Mestranol --c.cn HO --CiCH CHJO / Acta obst. et gynec. scandinav. Vol. XLVIII, suppl. 1, 1969.

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