Untersuchungen über die innere Sekretion des Corpus luteum

The action oe progesterone on the uterus of the rabbit and its antagonism by œstrone

“…The results obtained in vitro are in agreement with those of Ma kep e a c e, Corner & Allen [1936]. In view of the results of Robson &Illingworth [1931] andof De Fremery, Luchs &Tausk [1932] it still seems possible that there is present in crude extracts of the corpus luteum a substance capable of producing desensitization and not progestational proliferation.…”

“…For the sake of clarity this phenomenon will be referred to as desensitization of the uterus. Investigations with various fractions of a crude extract of the corpus luteum have shown that the degree of desensitization to oxytocin in vitro does not always run parallel with the effect (progestational proliferation) of the luteal hormone on the endometrium [Robson & Illingworth, 1931;De Fremery, Luchs & Tausk, 1932], and have suggested the possibility that the active factors responsible for the actions on the uterine muscle and endometrium respectively may not be identical. In view of the recent isolation and partial synthesis of progesterone, the active principle of the corpus luteum, it was decided to determine to what extent the known actions of the luteal extracts on the uterus could be attributed to this substance and the first part of this paper records the results obtained.…”

Studies of Basophils

“…There exists, however, experimental evidence that a progestational state induced by progesterone or chorionic gonadotropin cannot be extended beyond 17 ±2 days without progestational activity break ing down for 48 hours. With continued treatment the progestational state can again be induced for one or more phases of similar length (9,10). It would, therefore, seem possible that the increase in baso phil numbers during midpregnancy was brought about by a similar shift away from progesterone dominance as the rise which preceded parturition.…”

Reactions of the Uterine Muscle and Endometrium of the Rabbit to Testosterone

“…Experiments with various fractions of a crude extract from corpora lutea have given results which suggested that the inhibitory action does not always vary with the effect (progestational proliferation) on the uterine endometrium [Robson and Illingworth, 1931;De Fremery, Luchs, and Tausk, 1932], and suggested the possibility that other substances besides progesterone may produce an inhibitory action on the uterine muscle. In view of the recent isolation in crystalline form of a series of compounds with "male hormone" properties, it was decided to investigate the action of some of them on the rabbit's uterus.…”