Objective:The aim of the Advanced Approach to Arterial Stiffness study was to compare arterial stiffness measured simultaneously with two different methods in different age groups of middle-aged and older adults with or without metabolic syndrome (MetS). The specific effects of the different MetS components on arterial stiffness were also studied.Methods:This prospective, multicentre, international study included 2224 patients aged 40 years and older, 1664 with and 560 without MetS. Patients were enrolled in 32 centres from 18 European countries affiliated to the International Society of Vascular Health & Aging. Arterial stiffness was evaluated using the cardio-ankle vascular index (CAVI) and the carotid–femoral pulse wave velocity (CF-PWV) in four prespecified age groups: 40–49, 50–59, 60–74, 75–90 years. In this report, we present the baseline data of this study.Results:Both CF-PWV and CAVI increased with age, with a higher correlation coefficient for CAVI (comparison of coefficients P < 0.001). Age-adjusted and sex-adjusted values of CF-PWV and CAVI were weakly intercorrelated (r2 = 0.06, P < 0.001). Age-adjusted and sex-adjusted values for CF-PWV but not CAVI were higher in presence of MetS (CF-PWV: 9.57 ± 0.06 vs. 8.65 ± 0.10, P < 0.001; CAVI: 8.34 ± 0.03 vs. 8.29 ± 0.04, P = 0.40; mean ± SEM; MetS vs. no MetS). The absence of an overall effect of MetS on CAVI was related to the heterogeneous effects of the components of MetS on this parameter: CAVI was positively associated with the high glycaemia and high blood pressure components, whereas lacked significant associations with the HDL and triglycerides components while exhibiting a negative association with the overweight component. In contrast, all five MetS components showed positive associations with CF-PWV.Conclusion:This large European multicentre study reveals a differential impact of MetS and age on CAVI and CF-PWV and suggests that age may have a more pronounced effect on CAVI, whereas MetS increases CF-PWV but not CAVI. This important finding may be due to heterogeneous effects of MetS components on CAVI. The clinical significance of these original results will be assessed during the longitudinal phase of the study.

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Objective: To investigate the association between tumor necrosis factor alfa (TNFa), N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and polymorphism of the M235T of the ATG gene in hypertensive patients with heart failure with preserved ejection fraction (HFpEF). Design and method: The main group of eighty-four patients (51 females and 33 males; mean age 62,7 ± 8,0 years) with HFpEF and arterial hypertension. Sixty-eight patients and eighteen healthy persons were carriers of 235T allele (MT+TT genotypes), sixteen patients had MM genotype of M235T polymorphism of ATG, determined by using of polymerase chain reaction. Levels of NTproBNP and TNFa were determined by enzyme-linked immunosorbent assay (ELISA) using «NTproBNP-BEST-ELISA» (Russia) and «TNFa-ELISA-BEST» (Russia), respectively. All statistical tests were 2-tailed and p < 0,05 was considered statistically significant and performed in Statistica 10.0. Results: The significant difference in the level of TNFa in hypertensive patients with HFpEF depending on the different genotypes of M235T polymorphism of ATG was not found. Although the serum NTproBNP level increased in patients with MT+TT genotypes compared with patients with MM genotype (Table 1). Conclusions: The presence of T allele of M235T polymorphism of ATG in hypertensive patients with HFpEF was independently associated with increased level of NTproBNP

Вперше наведено опис копролітів палеогенових хрящових риб Selachicoprus volgensis Khosatsky et Vialov із поховань Ак-кая та Пролом (Білогірський район, АР Крим). Отримані дані розширюють знання про іхнофосилії хребетних тварин палеогену та обґрунтовують перспективи їх подальших досліджень із кайнозойських відкладів України. Ключові слова: копроліти, еоцен, олігоцен, Крим. Впервые приведено описание копролитов эоценовых рыб Selachicoprus volgensis Khosatsky et Vialov из захоронений Ак-кая и Пролом (Белогорский район, АР Крым). Полученные данные расширяют знания об ихнофоссилиях позвоночных животных палеогена и обосновывают перспективы их дальнейших исследований из кайнозойских отложений Украины. Ключевые слова: копролиты, эоцен, олигоцен, Крым. First is a description of the Eocene fish coprolites Selachicoprus volgensis Khosatskyet Vialov of sections Ak-kaya and Prolom (Belogorsky region, Crimea). The data obtained are expanding information about trace fossils vertebrates Paleogene and justify their prospects further researches of Cenozoic deposits of Ukraine.