A combination of platelet count and APTT is probably a practical and cost-effective combination to screen for consumptive coagulopathy in PE.

Objective: To document episodic syndromes that may be related to migraine (International Classification of headache disorders edition 3-beta versions, code 1.6) and to suggest two clinically useful markers for diagnosing episodic syndromes. Methods:Children and adolescents aged 3 years to 15 years presenting with recurrent head pain of definite / probable migraine origin were interviewed along with their parents or accompanying family member over a period of 2 years (October 2013 to September 2015). Present and past histories of symptoms suggestive of episodic syndromes were documented. ICHD-3 beta diagnostic criteria applied in all cases.Results: 176 fulfilled the ICHD-3 beta diagnostic criteria for episodic syndromes. Abdominal migraine in 98, brief episodes of vertigo / imbalance suggestive of benign paroxysmal vertigo were reported by 62, Cyclical vomiting in 14 and Benign paroxysmal torticollis in 2.124 (70%) were getting these symptoms when exposed to common migraine triggers in this region. Either a single trigger or combination of triggers precipitated these manifestations. 144 (88%) first or second degree siblings were suffering from migraine (1.1, 1.2, 1.5 or brief migraines). Conclusion:Episodic syndromes are not rare in daily clinical practice. Documenting Common migraine triggers and family history of migraine will make episodic syndrome diagnosis easier in children and adolescents.

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Flunarizine, a potent calcium channel blocker has been used for more than three decades for the prophylactic management of migraine. Theories suggest that flunarizine may act through multiple mechanisms such as inhibition of cortical spreading depression, neurogenic inflammation and channelopathy. Flunarizine is efficacious in the management of various types of migraines such as common, classical, vestibular, abdominal, hemiplegic and pediatric migraine. It has a manageable safety profile with weight gain and drowsiness being commonly reported.

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