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The aim of the study of the study is to evaluate the current diagnostic capabilities and improve the method of surgical treatment of patients with NET of the small intestine. Materials and methods: The results of treatment of 68 patients with NET of the small intestine (SI) were studied. Localized tumors were diagnosed in 5,9% of patients, locally spread – 22%, generalized – in 72,1%. Diagnostics of SI-NET included: assessment of clinical manifestations of the disease; laboratory diagnostics (CgA, serotonin, 5-HIAA), instrumental examination (US, CT, MRI, PET-CT 68Ga-DOTA-TATE); morphological examination (histological, immunohistochemical) of the tumor. Results: Late diagnosis of SI-NET is due to an asymptomatic course of the disease in 27,9% of patients, and non-specific clinical manifestations in 29,4%. The sensitivity of CgA, serotonin, 5-HIAA in the diagnosis of localized and locally distributed tumors is 11,1%, 45,5%, 20%, generalized – 59,3%, 86,2% and 50% respectively. The main method for diagnosing neo of the small intestine is CT, which is informative in detecting a tumor of 20%, and mesentery conglomerate – 94.5%. Surgical treatment was performed in 75% of patients. Cytoreduction or removal of the primary tumor increases the life expectancy of patients with generalized NET by 2 times. The developed method of surgical treatment of patients with SI-NET with extensive local distribution, which provides radical surgical intervention. Conclusion: Difficulties in diagnosing SI-NET are due to the peculiarities of the clinical course of the disease. The surgical method is the main one in the treatment of patients at all stages of the oncological process. The proposed techniques of surgery allow performing resection of the small intestine and removing the tumor conglomerate of the mesentery without compromising the functional and oncological results of treatment of patients.

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Objective. To study modern diagnostic capabilities and identify available ways to improve the results of treatment of patients with NET of the digestive organs. Neuroendocrine tumors (NET) are neoplasms difficult to diagnose and treat, which are localized mainly in the digestive tract. Materials and methods. The results of observation of 325 patients with NET were studied: gastrointestinal tract in 189 (58.1 %) persons, pancreas in 125 (38.5 %), without established localization in 11 (3.4 %). NET of various malignancy prevailed 92.3 %. Laboratory diagnostics included tumor markers (CGA, serotonin, 5-HIAA, etc.), instrumental endoscopic (FGS, FCS), radiation (US, CT, MRI), radioisotope (PET-CT with 18-FDG, 68-Ga-peptides) and morphological (histology, immunohistochemistry) research. Results. Nonspecific symptoms were noted in 3848 % of patients, asymptomatic course in 2025 %. The sensitivity of CGA was 54 %, serotonin and 5- HIAA depended on the presence of carcinoid syndrome and the prevalence of the tumor. Multiphase CT is the main method of diagnosis of small intestinal NET, which allows you to differentiate pancreatic NET by the degree of malignancy. The surgical intervention provides the best results in the treatment of patients with non-metastatic NET, but in case of generalized tumors, its combination with antitumor therapy prolongs the duration of life in patients by 2 times. Conclusions. Personalized therapeutic and diagnostic tactics, taking into account the clinical and morphological features of NET, ensures optimal detection and treatment, improves survival and quality of life among patients.