Abstract:AIM: 1. To determine Thyroid dysfunction and antiTPO antibody status in pregnant women. 2. To know the benefit of LT 4 therapy in maternal pregnancy outcome (antiTPO ab+ve vs antiTPO ab-ve groups) and 3. To determine the maternal and fetal outcomes in hypothyroid pregnant women and to decide whether universal screening of pregnant women for hypothyroidism is required or not. Materials and methods: A prospective study was done in mamata general hospital in the dept. of obg, over a period of 1 ½ years.105 antenatal women were included in the study.Outcome in these pregnancies were observed and analysed using appropriate statistical method.Results: There were only 3 patients with spontaneous abortions, 3 patients with pregnancy induced hypertention and only 1 patient had preterm delivery.There was more of thyroid dysfunction in anti TPO Ab +ve cases.But there was no significant adverse effect on pregnancy outcome in patients who were treated. Conclusion: Though our study included only a small number of antenatal women who were screened for thyroid abnormality since it was only a pilot study done in our hospital since our area is endemic for thyroid disorders due to iodine deficiency we recommend Universal screening to rule out thyroid dysfunction in pregnancy because the maternal and fetal complications can be reduced by early screening, diagnosing and correcting thyroid abnormality .

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Background: Anaemia is the most common medical disorder in pregnancy and is responsible for higher of the maternal deaths in the developing countries. Objective: To determine the efficacy of intravenous iron sucrose, in anemic pregnant women, presenting at Mamata General Hospital, Khammam. Methods: Fifty patients with proved iron deficiency anemia having haemoglobin between 8-10gm% were included in the study. Total iron deficit was calculated by standard formula. Target haemoglobin to be achieved was 11gm%. Iron sucrose was administered by intravenous infusion in divided doses. Haemoglobin was repeated 3 weeks after the last dose of intravenous iron sucrose. Gestational Age, Socio economic class distribution was calculated in percentage , Pre and post treatment Hb% was calculated by mean and standard deviation and P-value was Assessed. Results: Majority of the patients i.e. 60% had gestational age between 32-34 weeks, 30% were in between 29-31 weeks of gestational age while 10% were between 26-28 weeks gestation. The Mean gestational age was 32.4±2.7. Distribution of cases by socio economic status showed, 40% belonged to lower class, 32% belonged to middle class and 28% were from upper class. Intravenous iron sucrose therapy was effective in 90% of the patients without any side effects. There were no allergic reactions. Conclusion: This study showed a significant improvement in the haemoglobin of the patients who received iron sucrose infusion. Patients achieved the target of 11 gram % haemoglobin. It was safe and well tolerated.

Aim: To study the maternal and fetal outcome in antenatal mothers who were suffering from dengue fever. Methods: A prospective analysis of 56 pregnant women admitted in obstetric ward with dengue fever over a period of 12 months was done and results were observed and documented. Analysis was done with respect to age of patient, gestational age of pregnancy, complications at presentation, laboratory diagnosis, platelet counts and treatment offered. Outcome of pregnancy like abortion, pre-term delivery, term delivery, birth weight and condition of fetus at birth were noted. Maternal mortality and morbidity were also noted. Results: Majority of the patients were in between 26-30 years of age and was in second and third trimesters. The striking feature observed was the presence of severe thrombocytopenia in three fourth of the study population. Eight patients had platelets <10,000 cells /mm 3 and all of them received massive platelet transfusions. Thirty six patients had platelet count in between10,000 to 50,000 cells/mm 3 , only 20 patients received 4-5 units of platelet transfusions. In addition, coexistence of other vector borne diseases was also noted. Other associated complications are: dengue hemorrhagic fever (12), pregnancy induced hypertention (12), disseminated intravascular coagulation (4), respiratory stridor (4) and malaria (4) with dengue fever. Most of them had a term vaginal delivery and some had caesarian section. Eight of them had abortion. Conclusion: Most cases required only conservative treatment. Women who went into labour required platelet transfusion. Outcome seemed to correlate with gestational age of occurrence of dengue fever.

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