The situation with dyspepsia of young animals in the postnatal period in agroindustrial companies of Russia remains tense due to a high mortality rate. Specialists are not always able to cover a wide range of drugs currently available on the market, although the success in combating the disease depends on a timely introduction of highly effective drugs and various combinations of treatment regimens into practice. The paper presents the findings of studies on the use of various treatment regimens for dyspepsia of newborn calves, with the inclusion of an immunomodulator. The studies have shown high therapeutic efficacy of both antibacterial drugs Cobactan and Neopen, and their use in combination with the drug Phosprenyl. Laboratory studies of morphological and biochemical parameters of blood demonstrated significantly improved concentration and percentage of the drugs. In the course of treatment with basic drugs, the immunomodulator Phosprenyl enhanced their action and positively affected the percentage composition of the leukoformula. Daily clinical examination of young experimental animals showed that treatment with Cobactan, especially in combination with Phosprenyl, is most effective in terms of fastening recovery and safety of calves.