The influence of KOH concentration (8 and 12 M) and curing conditions as temperature (40˚C and 60˚C), time (7 and 28 days) and relative humidity (85% and 95% RH), on compressive strength of metakaolin-based geopolymers (MK-based GP) was evaluated. Derived from the experimental design technique, and using a factorial design 2 K with two replications in the center point, eighteen experiments were conducted. The results reveal that the best performance conditions of geopolymerization to develop a higher compressive strength of 20 MPa are 12 M KOH to 60˚C and 85% RH at 28 curing days. With these conditions, the value of relative humidity of 85%, promotes high strength compact samples, and a maximum of 42 MPa at 90 days. The results of significant, compressive design of GP showed that KOH concentration and curing relative humidity were the most important factors, followed by curing time and temperature. The GP were characterized by XRD, and their evolution on compression strength was followed by SEM.