The article presents the results of the research into optoelectronic emission of blood and its components before and after oxidation, the features of the emission parameters describing the positional order of molecular bindings, as well as the features of intermolecular interactions before and after exposure to oxidative stress on whole blood and its components. The revealed changes can be the basis for determining the mechanism of oxidative and reduction processes occurring in associations of protein molecules of cardiovascular system under the influence of environmental factors or chemical effects. It is proven that the markers of oxidative stress on whole blood and its components must be related to the parameters of the angular and energy distribution of the emitted electrons.
The therapeutic efficiency of medicines containing the same active ingredient depends on the production technology, as well as the excipients included in the tablet and the type of shell. In this work, we consider some of the possibilities of using the gas-discharge visualization method based on the phenomenon of channeling electrons through a liquid medium to study aqueous solutions of medicines. The study was carried out on the example of the passage of kilovolt electrons through drops of solutions of the beta-blocker bisoprolol, produced by various pharmacological companies. We studied bisoprolol preparations without excipients and bisoprolol preparations with excipients. The obtained differences in the characteristics of the gas-discharge luminescence for the studied medicines open up prospects for assessing the quality and pharmacological efficiency of medicines, and, subsequently, for the individualization of medicines therapy.
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