Introduction: Pedunculated lipofibroma is a challenging case. It’s a slow growing mass lesion which can affect both children and adult. The diagnosis of pedunculated lipofibroma can be confused with other benign papillomas due to their characteristic appearance. Objective: To define the clinicopathological findings of pedunculated lipofibroma. Methodology: Descriptive study as case report type, which use secondary data from patient medical record. Case presentation: This paper reports a 39-year-old woman, who has a slow growing mass lesion on her left thigh for almost 3 years. The lesion start impending her daily life due to pain and the lesion get bigger which make her get trouble especially when she wants to wear her jeans. The diagnosis of pedunculated lipofibroma can be confirmed by the histopathologic findings showing isolated groups of ectopic mature adipocytes within the dermis. Generally, the tumor itself doesn’t need any specific treatment, however the location and size affect the patient performance. Conclusion: Based on clinicopathological findings, the patient diagnosed with solitary pedunculated lipofibroma located at medial femur sinistra.

Introduction: Histopathological features of the lung parenchyma due to the Alveolar-Pleural Fistula (APF) in a patient with post-COVID-19 infection have not been reported. APF usually occurs after a spontaneous pneumothorax. Spontaneous pneumothorax is an abnormal traumatic accumulation of air within the pleural space. It is classified as primary or secondary pneumothorax based on multiple risk factors.Case Presentation: A sixty-four-year-old patient was referred from one of the remote hospitals in the west of Bali due to spontaneous simple pneumothorax dextra. A week after being diagnosed with COVID-19 infection, the patient underwent a bullectomy procedure and was clinically diagnosed with recurrent spontaneous pneumothorax dextra due to APF. Then, the bullectomy specimen was sent to the anatomical pathology laboratory. Histopathology test revealed extensive areas of necrosis and fibrosis with scattered lymphocytes and emphysematous alveoli found in APF lesions. Conclusions: In conclusion, the evidence of extended fibrosis, which destroys the pulmonary parenchymal septum and dilated alveoli with diffuse fibrosis in the subpleural and intraparenchymal areas, may cause impairment of both perfusion and ventilation. Unfortunately, viral cytopathic like-changes related to COVID-19, such as multinucleated cells with large nuclei, amphophilic cytoplasm, and prominent nucleoli in alveolar spaces with intranuclear inclusions, were not found in this case. In this case, surgery is needed in case of fistula, either related or unrelated to infection of the pleural cavity indicating the patient’s functional recovery.