Introduction: Data on outcomes of transcatheter mitral valve repair (TMVR) in patients with acute kidney injury (AKI) remains limited. Hypothesis: AKI is associated with worse outcomes in patients undergoing TMVR Methods: We utilized the United States National Inpatient Sample database from the year 2015 to 2018 to evaluate outcomes of TMVR in AKI. Results: A total of 21,505 weighted hospitalizations were included in the analysis. Of the patients who underwent TMVR 3350 (15.6%) developed acute kidney injury. The mean age of patients undergoing TMVR was higher for patients with AKI compared to patients who did not develop AKI was 77 and 76 years respectively. A logistic regression model adjusted for age, gender and baseline comorbidities was developed for predictors of AKI. On adjusted comparison liver disease (OR 2.4 95% CI, 2-2.9), peripheral vascular disease (1.35, 95% CI 1.2-1.53), congestive heart failure (2.76 95% CI, 2.34-3.26) and history of weight loss (1.92 95% CI 1.64-2.25) were significant predictors of AKI. In-hospital mortality was higher for patients with AKI versus no AKI (10.1% vs. 0.7%, p<0.01). Length of stay (13 vs 3 days) and cost of stay ($80787 vs. $ 44086) was significantly higher for patients with AKI versus those who did not develop AKI. Conclusions: AKI is associated with increased in hospital mortality and increased health care resource utilization in patients undergoing TMVR.

Introduction: Data on outcomes and predictors of gastrointestinal (GI) bleeding in patients undergoing percutaneous mitral valve repair (PMVR) remains limited. Hypothesis: GI bleed is associated with worse outcomes in patients undergoing PMVR Methods: We utilized the national inpatient sample data from the year 2015 to 2018 to evaluate outcomes and predictors of GI bleed in patients undergoing PMVR. Results: A total of 21,505 weighted hospitalizations were included in the analysis. Of the patients who underwent PMVR, 285 (1.3%) developed GI bleed whereas 21220 (98.7%) did not have in-hospital GI bleed event. The mean age of patient with and without GI bleed was 77 and 76 years respectively (P<0.01). A logistic regression model was developed for adjusted comparison based on age, gender and baseline comorbidities. On adjusted comparison history of MI (OR 1.56, 95% CI 1.17-2.08), congestive heart failure (OR 1.79, 95% CI 1.18-2.73), African American race (OR 1.75, 95% CI 1.16-2.66) and history of weight loss (OR 2.71, 95% CI 1.97-3.74) were associated with significantly increased risk of gastrointestinal bleeding. Patients who developed GI bleed had significantly higher in-hospital mortality (8.8%) compared to non-GI bleeders (2.1%). Length of stay (16 vs. 4 days) and cost of hospitalization ($ 66118 vs. $49167) was significantly higher for GI bleeders undergong PMVR. Conclusions: In conclusion we report that GI bleed is associated with higher in-hospital mortality and resource utilization in patients undergoing PMVR.