The traditional medical methods, especially the use of medicinal plants still play a major role in the developing countries. The history of the use of herbal medicine may be as old as the history of mankind. Many of the herbs and spices used by humans as food which yields useful medicinal compounds. Annona muricata L. leaves are traditionally used to treat diabetes. People have been consuming raw leaves of Annona muricata L. to control blood glucose levels. The acetone, methanol, hot water and successive water leaf extracts of Annona muricata L. were subjected to preliminary phytochemical screening of various plant constituents. The antioxidant potential of the Annona muricata L. leaves was established by total flavonoid content, FRAP assay, ABTS assay, Metal chelating activity, Phosphomolybdenum assay, Assay of superoxide radical scavenging activity, Free radical scavenging activity on DPPH along with the determination of total phenolic and tannin contents in the Annona muricata L. leaves extracts. This study aim is to evaluate bioactive constituents and invitro antioxidant activity of acetone, methanol, hot water and successive water extracts of Annona muricata L. leaf. Preliminary analysis revealed that all the four extracts responded positively for alkaloid, flavonoid, carbohydrate, glycosides, saponins, tannin, phytosterol and phenolics. The present study explored that Annona muricata L. shows efficient antioxidant activity and could act as safe and cost-effective with potential biological applications.

Background: In recent years, nanotechnology research is emerging as cutting edge technology interdisciplinary with physics, chemistry, biology, material science and medicine. AuNPs and AgNPs are an important class of nanomaterial for a wide range of biomedical applications. Synthesis of AuNPs and AgNPs through biological route is preferred due to its environment-friendly and economic aspects. Mushrooms have been known for their nutritional values and used as medicines by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. The present study demonstrates an eco-friendly and low-cost method of biosynthesis of AuNPs and AgNPs using basidiomycetes mushroom fungal strains. Materials and Methods:The antioxidant potential of the basidiomycetes mushroom fungal strains was analysed by total flavonoid content, FRAP assay, ABTS assay, Metal chelating activity, Phosphomolybdenum assay, Assay of superoxide radical scavenging activity, Free radical scavenging activity on DPPH along with the determination of total phenolic and tannin contents in the mushroom mycelial extracts. Results: The synthesized gold nanoparticles (AuNPs) silver nanoparticles (AgNPs) were confirmed by

Mushrooms are used for a variety of biotechnological applications, particularly for the production of food, enzymes, dietary supplements, pharmaceutical compounds, feed supplements. Basidiomycetes mushroom fungi have been known for their nutritional values they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. Mushroom represents a major and untapped source of potent new pharmaceutical products. A wide range of activities including antitumour, cardiovascular and antimicrobial are reported in mushrooms. In developing countries like India mushroom progress is a boon in the field of food, medicine, and in generating employment. The alternative systems of medicine utilize the curative properties of mushrooms. They are also known to possess promising antioxidative, cardiovascular, hypercholesterolemia, antimicrobial, hepato-protective and anticancer effects. The present study aimed to evaluate antimicrobial and antihaemolytic activities of various extracts of Basidiomycetes mushroom fungi. Different Basidiomycetes mushroom fungi extracts (Hot water, Acetone and Hexane) were tested for antimicrobial and antihaemolytic activities. Among these different extracts of Basidiomycetes mushroom fungi the hexane extract of Pleurotus pulmonarius showed potential antimicrobial and antihaemolytic activity. The results of this study suggest the possibility of using Basidiomycetes mushroom fungi as natural sources for the pharmaceutical industry and could act as safe and cost-effective with potential biological activities. These findings encourage studying these fungal strains further for their potential biological applications.

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