No abstract

Cardiac circadian rhythms are an important regulator of body functions, including cardiac activities and blood pressure. Disturbance of circadian rhythm is known to trigger and aggravate various cardiovascular diseases. Thus, modulating the circadian rhythm can be used as a therapeutic approach to cardiovascular diseases. Through this work, we intend to discuss the current understanding of cardiac circadian rhythms, in terms of quantifiable parameters like BP and HR. We also elaborate on the molecular regulators and the molecular cascades along with their specific genetic aspects involved in modulating circadian rhythms, with specific reference to cardiovascular health and cardiovascular diseases. Along with this, we also presented the latest pharmacogenomic and metabolomics markers involved in chronobiological control of the cardiovascular system along with their possible utility in cardiovascular disease diagnosis and therapeutics. Finally, we reviewed the current expert opinions on chronotherapeutic approaches for utilizing the conventional as well as the new pharmacological molecules for antihypertensive chronotherapy.

The in vivo hepatoprotective activity of Homalomena aromatica was evaluated in carbon tetrachloride-induced hepatic injury model in Swiss albino mice. Effects of the methanolic rhizome extracts of Homalomena aromatica (HAME) at a dose of 200 mg/kg body weight and 500 mg/kg body weight was tested for its efficacy on CCl4 (1ml/kg body weight) induced liver injury. Hepatic toxicity enzyme markers and histological parameters were studied. Daily oral administration of HAME (500 mg/kg) reduced liver toxicity marker enzyme activity significantly as compared to the control. The results were also supported by the histopathological studies. Recovery of the liver tissue was observed in the highest dose (500 mg/kg) of HAME. The progression of liver damage could be inhibited by the protective effect of HAME and the normal architecture of the liver could be preserved. The plant can therefore be a potential therapeutic candidate to treat liver injury.

This Study tries to investigate the impact of demographic profile, moral science and social service, more specifically the social responsibility in developing secondary school students’ perception about social responsibility and how they contribute towards their holistic development. This is exploratory research based on a modest sample of 120 respondents drawn from various secondary schools in Kolkata, India through judgement sampling method.