No abstract

Elaeis guineensis Jacq. (Arecaceae), encore appelée Palmier à huile, constitue une source de nourriture et un remède naturel contre plusieurs pathologies. La présente étude avait pour but d’évaluer l’activité cicatrisante de l’extrait aqueux des feuilles de E. guineensis dans un modèle de brûlures expérimentales de second degré chez le rat de souche Wistar. Deux pommades à 3 et 10% de l’extrait aqueux dans la vaseline (EGV-3% et EGV-10%) ont été utilisées pour le test. Au plan phyto-chimique, l’extrait aqueux renferme des tanins, des flavonoïdes, des alcaloïdes et des stérols-triterpènes. L’application quotidienne des pommades induit une cicatrisation dépendante de la concentration. La vitesse de cicatrisation est plus importante avec EGV-10%, qui induit une réparation tissulaire quasi complète au bout de 22 jours de traitement. Les résultats de cette étude montrent l’intérêt de l’utilisation en milieu traditionnel des feuilles de E. guineensis dans la cicatrisation des plaies et des brûlures.Mots clés : plantes médicinales, brûlures, plaies, cicatrisation   English Title: Wound healing activity of the aqueous leaf extract of Elaeis guineensis Jacq. (Arecaceae) Elaeis guineensis Jacq. (Arecaceae) still called Palm Oil, is a source of food and a natural remedy against several diseases. The purpose of this study was to assess the healing activity of the aqueous leaf extract of E. guineensis in second-degree experimental burn model in Wistar strain rat. Two ointments (3 and 10%) of the aqueous leaf extract in the vaseline (EGV-3% and EGV-10%) were used for the test. Phyto-chemically, the aqueous leaf extract contains tannins, flavonoids, alkaloids and sterols-triterpenes. Daily application of ointments promotes a concentration-dependent healing. The cicatrization rate is higher with EGV-10%, which induces near-complete tissue repair after 22 days of treatment. These results show the value of traditional using of E. guineensis leaves in the healing of wounds and burns.Keywords: medicinal plants, burns, wounds, cicatrization.  

No abstract

Elaeis guineensis Jacq. is an arborescent monocotyledon of the Arecaceae family. It is a plant originated from tropical rainforest of West Africa. For centuries, it has been a source of food and a natural remedy against several pathologies. The aim of the present research was to evaluate antiinflammatory and analgesic activities of methanolic extract E. guineensis Jacq. (Arecaceae) leaves and phytochemical groups. Extraction with methanol and various liquid-liquid fractionations were carried out. These extract and fractions were administered orally at different doses. The experiments were performed on models of carrageenan-induced inflammatory edema in rat and acetic acid-induced pain in mouse. The extraction protocols gave a methanolic extract and different fractions, methanolic tannins free, alkaloid, terpenoid, and flavonoid. The methanolic extract administered at doses of 1, 3 and 10 mg/kg significantly prevents inflammatory edema. The percentages of increase in edema 5 h after induction are 38.31±3.55, 37.48±4.98, 40.82±4.14 versus 92.72±6.05 in the control group. The same profiles are observed with the methanolic fractions tannins free, flavonoid and terpene. However, the latter show dose-dependent activities between 1 and 3 mg/kg. The methanol fraction tannins free at 3 mg/kg is better in preventing inflammatory edema. Oral tannin-free methanolic fraction significantly prevents acetic acid-induced pain in mice. Elaeis guineensis leaves possess anti-inflammatory and analgesic properties on models of carrageenan-induced inflammatory edema in rat and acetic acidinduced pain in mouse. The anti-inflammatory and analgesic activities could be linked to the combined action of alkaloids, flavonoids and terpenes, on the different targets of the inflammatory reaction.