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The nephroblastoma is the third pediatric cancer in Mali, this study aimed to describe the prevalence and prognosis of nephroblastoma relapses. Methods: It was a descriptive retrospective study over a 10-year period from January 2005 to March 2015. We collected children aged 0 to 15 years followed for relapse of nephroblastoma in the pediatric oncology unit of university hospital center (UHC) Gabriel Toure. Results: The frequency of relapse of nephroblastoma was 7.4% (19 cases) whose mean age was 42 months with a sex ratio of 1.3. The relapse occurred before the end of the postoperative course in 16% of cases (3 patients). It was local recurrence in 52% of cases (10 patients), pulmonary 16% (3 patients), and hepatic 11% (2 patients). According to the SIOP classification, 47% of patients were diagnosed in stage III (9 patients) and 21% (4 patients) in stage IV. The tumor was high risk in 37%. Palliative chemotherapy was performed in 63% of the patients (12 patients) and the remaining seven were put on a high risk diet. The overall survival at 5 years was 21% or 4 patients. Conclusion: Our results showed all the difficulties in the management of nephroblastoma relapses in our context.

BACKGROUND and OBJECTIVE: Isoniazid preventive therapy (IPT) is known to reduce the risk of developing active TB in about 59% in children aged 15 years. We assessed adherence, completion and adverse events among children who were household contacts of a newly diagnosed adult with smear-positive TB in Bamako, Mali.METHODS: Children aged <15 years living in the same house with an adult smear-positive index case were enrolled in the study in the Bamako Region after consent was obtained from the parent or legal guardian. Adherence was assessed based on the number of tablets consumed during 6 months.RESULTS: A total of 260 children aged <15 years were identified as household contacts of 207 adult patients with smear-positive TB during the study period. Among all child contacts, 130/260 (50.0%) were aged 0–4 years and were eligible for IPT; 128/130 (98.5%) were started on IPT and 83/128 (64.8%) completed with good adherence at the end of the 6 months, and without any significant adverse events.CONCLUSION: We successfully implemented IPT with good acceptance, but low completion rate. The Mali National TB Program and partners should expand this strategy to reach more children in Bamako and the whole country and create greater awareness in the population.

La bilharziose génitale chez la femme se trouve principalement dans le col de l'utérus et le vagin, moins fréquemment sur la vulve et dans les trompes de Fallope et les ovaires, et rarement dans le corps de l'utérus. Nous rapportons le cas d´une fille, âgée de 10 ans, admise pour tuméfaction vulvaire, chez qui l'histologie a conclu à une bilharziose cutanée à Schistosoma haematobium. L'évolution a été favorable sous praziquantel 40 mg/kg en une prise unique avec régression de la tumeur.

Context: First cause of seeking for urologic consultation in the world, chronic prostatitis is a real public health care problem. Objective: Analyze epidemioclinical aspect of chronic prostatitis/chronic pelvic pain syndrome (CP⁄CPPS) and proceed in management assessment. Patients and methods: Descriptive Prospective and analytique study about all CP/CPPS admitted in our service from 1 st January 2016 to 30 October 2016. Results: Fifty fours (54) patients have been enrolled, accounting for 9.85% of our activities. Mean age: 36.24±13.44. The majorities (87, 50%) of our patients were celibataire or married, but living separated to their wife. They were doing anxiogenic and prolonged sitting activities (Car driver, Seller, Tailor). The most frequent (60%) clinical manifestation was Pelviperineal and/or testicular pain. Complaints were often associated to uretrovesical obstruction and irritation Signs, sexual dysfunction. Digital rectal examination tenderness was the only physical examination founding. We found solely 4 cases of PCB type II with E Coli as germ responsible. PCNB type IIIA was the most prevalent (48%). Systematical antibiotherapy based on quinolone using alone or in combination with azithromycin has been adopted. It's associated to AINS, alpha blockers and anxiolytis. Therapeutic result has been evaluated during 4-6 months after treatment and was judged satisfactory (NIH-CPSI decrease of 6 points) for 72.50% patients. Conclusion: Multimodal treatment taking account to the main symptom and socioprofessional habits is the only way for good result. It necessary to found new bio markers in the aim to help for diagnostic and treatment result assessment.