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Transcatheter aortic valve replacement is a validated therapeutic option for severe symptomatic aortic stenosis. Dextrocardia with total situs inversus is a rare heart condition (1 in 12,000). We present an interesting case of transcatheter aortic valve replacement with a CoreValve Evolut R (Medtronic, Minneapolis, Minnesota) through a transfemoral approach in a patient with dextrocardia and situs inversus. ( Level of Difficulty: Intermediate. )