Fibrin Clot Properties and Cardiovascular Disease

Undas, Anetta; Zeglin, Magdalena

doi:10.2174/1567270000603010016

Cited by 5 publications

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“…The structure and function of the fibrin clot are modulated by several environmental and genetic factors [7,8]. Total homocysteine (tHcy) [9], lipoprotein(a) [Lp(a)] [10] and Creactive protein (CRP) [11], which along with fibrinogen are significantly elevated in haemodialysis patients, have also been reported to reduce clot permeability and susceptibility to lysis.…”

Section: Introductionmentioning

confidence: 99%

Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality

Undas

Kolarz²,

Kopeć

et al. 2008

Nephrology Dialysis Transplantation

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Background. Haemodialysis patients are at an increased risk of cardiovascular (CV) morbidity and mortality. Both end-stage renal disease (ESRD) and thromboembolic coronary events have been shown to be associated with the formation of dense fibrin clots resistant to fibrinolysis. The aim of the present study was to investigate the effect of longterm haemodialysis on clot structure/function and analyse an influence of markers of inflammation, oxidative stress and lipoprotein(a). We sought also to investigate if clot features might be related to CV events and mortality in haemodialysis patients. Subjects and methods. In 33 patients (19 males, 14 females), aged 27 to 89 years, on long-term haemodialysis and 33 age-and sex-matched apparently healthy controls, we investigated fibrin clot properties and susceptibility to lysis using recombinant tissue plasminogen activator by using permeation and turbidity assays. Results. Haemodialysis patients produced fibrin clots that had less porous structure (P < 0.0001) were less susceptible to fibrinolysis (P < 0.0001), began fibrin protofibril formation more quickly (P < 0.0001) and showed increased overall fibre thickness (P < 0.0001) compared with controls. Clot permeability and lysis time correlated with F2-isoprostanes (P < 0.01), Lp(a) (P < 0.0001) and fibrinogen (P < 0.01). None of the clot variables showed associations with the duration of haemodialysis treatment or the cause of ESRD. During a 36-month follow-up, 10 CV deaths were recorded. Mortality was associated with reduced clot permeability (P < 0.0001), prolonged lysis time (P < 0.0001), faster fibrin protofibril formation (P = 0.0004), thicker fibres (P < 0.0001) and increased fibrin clot mass (P < 0.0001). Conclusions. Unfavourably altered clot properties can be detected in haemodialysis patients and may be associated with increased CV mortality.

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Section: Introductionmentioning

confidence: 99%

Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality

Undas

Kolarz²,

Kopeć

et al. 2008

Nephrology Dialysis Transplantation

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“…It was previously documented that aspirin and statins can increase clot permeability and facilitate fibrinolysis 24 25 28 29. However, in CHF these effects seem to be diminished owing to processes such as platelet activation, free radical formation and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Altered fibrin clot properties in patients with chronic heart failure and sinus rhythm: a novel prothrombotic mechanism

Palka

Nessler

et al. 2010

Heart

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“…19,20 Altered plasma fibrin clot characteristics, as evidenced by reduced clot permeability and impaired fibrinolysis, have been reported in patients with acute or myocardial infarction in the past, 21,22 stable coronary artery disease, 23 peripheral artery disease, 24 idiopathic VTE, 25 diabetes, 26 chronic obstructive pulmonary disease, 27 and rheumatoid arthritis. 19,20 Altered plasma fibrin clot characteristics, as evidenced by reduced clot permeability and impaired fibrinolysis, have been reported in patients with acute or myocardial infarction in the past, 21,22 stable coronary artery disease, 23 peripheral artery disease, 24 idiopathic VTE, 25 diabetes, 26 chronic obstructive pulmonary disease, 27 and rheumatoid arthritis.…”

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confidence: 99%

Reduced Plasma Fibrin Clot Permeability and Susceptibility to Lysis in Patients with Inflammatory Bowel Disease

Owczarek

Cibor

Sałapa

et al. 2013

Inflammatory Bowel Diseases

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Fibrin Clot Properties and Cardiovascular Disease

Cited by 5 publications

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Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality

Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality

Altered fibrin clot properties in patients with chronic heart failure and sinus rhythm: a novel prothrombotic mechanism

Reduced Plasma Fibrin Clot Permeability and Susceptibility to Lysis in Patients with Inflammatory Bowel Disease

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