Background: Sevoflurane unfortunately increases the cranial blood flow, blood volume, and pressure changes cope with cerebral aneurysmal neuroanesthesia goals. Propofol decreases the brain metabolism, blood flow, preserve cerebral reactivity to carbon dioxide, creates neuroprotective effect during cerebral ischemia. Hypothesis: Propofol-based total intravenous anesthesia would be more appropriate than sevoflurane-based inhalational technique during surgical clipping of cerebral aneurysm. Methods: A prospective, randomized, comparative study on 50 patients subjected for elective clipping of cerebral aneurysm, randomly allocated into two equal groups of 25 patients each: propofol-dormicum total intravenous only group and sevoflurane based inhalational group. Results: Jugular oxygen saturation (primary outcome), cerebral blood flow equivalent, heart rate, mean arterial blood pressure, and end tidal carbon dioxide tension were statistically significantly decreased in propofol group compared to sevoflurane group at basal, just after dura opening, at 1,2,3 hours later, and after scalp closure. Arterio-Jugular oxygen content difference, cerebral extraction ratio of O 2 , estimated cerebral metabolic rate for O 2 , serum lactate (mg/dl) showed significant increase in propofol group compared to sevoflurane group at basal, 1, 2, 3 h, and after scalp closure. Duration of surgery, time of recovery, blood loss, blood transfusion, intraoperative complications, urine output, total midazolam consumption, surgeon satisfaction, intensive care unit stay time, and Ramsay sedation scale difference was not significant in between both studied groups during the early postoperative period. Conclusion: Propofol based total intravenous anesthesia has better cerebral oxygenation and neuro anesthesia profile compared to sevoflurane-based inhalational anesthesia during cerebral aneurysm clipping surgery with systemic hemodynamic stability.
