Background and Objective: Along with erythrocytes, the Kidd glycoprotein exists in the kidney, where it enables the kidney to accumulate an elevated urea concentration, which is required for the kidney to produce concentrated urine. The primary objective of this research is to look for Kidd genes (Jk) in patients with end-stage chronic kidney disease. Materials and Methods: This is a prospective cross-sectional study of 200 patients with chronic renal failure in Khartoum in the period from June 2018 to November 2021. The patients were being monitored in clinic and the majority of them were nearing the end of their chronic kidney disease (ESCKD). Results: When the positive and negative Jk Kidd antigens in ESCKD patients were compared, it was discovered that there were significant differences in urea (P-value 0.001), creatinine (P-value 0.001) and uric acid (P-value 0.04), but no difference in sodium or potassium. Conclusion:Kidd blood group influences serum urea, creatinine and uric acid levels significantly. This effect was observed in different Kidd blood group antigens, including Jka+, Jkb+ and Jka+b+. This means that the Jk group is important in estimating the severity of ESCKD; this discovery could be useful in determining dialysis time and treatment response.