Gupta, et al.: Apricot a medicinal plant Herbs are one of the most important sources of medicines for humans for confronting diseases and disorders. Even after several developments in the field of allopathic system of medicine, untoward reactions could not be prevented from being an integral part of modern medicines. Plants are one of the major sources of drug discovery in modern as well as traditional system of medicines worldwide. More than 70 % of marketed drugs are either natural or semisynthetic materials derived from plants. Most literature on complementary alternative medicine worldwide either report the structure of phytoconstituents present in medicinal plants or demonstrate a mechanistic basis for the pharmacological activities possessed by them. Medicinal and therapeutic impact of apricot has not been explored so far. In this review, an attempt has been made highlight the medicinal impact of apricot and its kernel for the treatment of alimentary disorders by summarizing published literature reports till date. Apricot exhibited diversified effects on liver regeneration to myocardial ischemia reperfusion.

A series of imines 5-amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamide derivatives were synthesized from various aromatic aldehydes and substituted with benzoyl acetazolamides under different reaction conditions and were evaluated for their antioxidant and free radical scavenging, antimitotic activity by Allium cepa meristem root model and cytotoxicity activity against HEK 293 (human epidermal kidney cell line), BT474 (breast cancer cell line) and NCI-H226 (lung cancer cell line) by MTT assay. Some of the synthesized compounds showed moderately potent cytotoxicity compared to indisulam. Graphical abstractA series of imines 5-amino-1,3,4-thiadiazol-2-[(N-substituted benzyol)]sulphonamide derivatives (9a–j); 5-amino-1,3,4-thiadiazol-2-[N-(substituted benzoyl)]sulphonamide (4a–g); 5-(4-acetamido phenyl sulphonamido)-1,3,4-thiadiazol-2-[N-(substituted benzoyl)]sulphonamide (6a–g); and 5-(4-amino phenyl sulphonamido)-1,3,4-thiadiazol-2-[N-(substituted benzoyl)]sulphonamide (7a–g) were synthesized from acetazolamide and were investigated for the in vitro anticancer by MTT assay, free radical scavenging and antimitotic activity by Allium cepa root meristem model. Experimental observations indicate that synthesized compounds were moderately potent anticancer agents.

A QSAR study was performed on sulphonamide-1,3,4- The compounds, ,3,4-thiadiazol-2-(N-benzoyl) sulphonamide (9a) and 5-(4-amino) benzenesulphonamido-1,3,4-thiadiazol-2-sulphonamide (10a)

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