A numerical study on heat transfer and entropy generation in natural convection of non-Newtonian nanofluid flow has been explored within a differentially heated two-dimensional wavy porous cavity. In the present study, copper (Cu)–water nanofluid is considered for the investigation where the specific behavior of Cu nanoparticles in water is considered to behave as non-Newtonian based on previously established experimental results. The power-law model and the Brinkman-extended Darcy model has been used to characterize the non-Newtonian porous medium. The governing equations of the flow are solved using the finite volume method with the collocated grid arrangement. Numerical results are presented through streamlines, isotherms, local Nusselt number and entropy generation rate to study the effects of a range of Darcy number (Da), volume fractions (ϕ) of nanofluids, Rayleigh numbers (Ra), and the power-law index (n). Results show that the rate of heat transfer from the wavy wall to the medium becomes enhanced by decreasing the power-law index but increasing the volume fraction of nanoparticles. Increase of porosity level and buoyancy forces of the medium augments flow strength and results in a thinner boundary layer within the cavity. At negligible porosity level of the enclosure, effect of volume fraction of nanoparticles over thermal conductivity of the nanofluids is imperceptible. Interestingly, when the Darcy–Rayleigh number $$Ra^*\gg 10$$ R a ∗ ≫ 10 , the power-law effect becomes more significant than the volume fraction effect in the augmentation of the convective heat transfer process. The local entropy generation is highly dominated by heat transfer irreversibility within the porous enclosure for all conditions of the flow medium. The particular wavy shape of the cavity strongly influences the heat transfer flow pattern and local entropy generation. Interestingly, contour graphs of local entropy generation and local Bejan number show a rotationally symmetric pattern of order two about the center of the wavy cavity.

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