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The COVID-19 pandemic unexpectedly stopped the steady life and enhanced environmental quality. To apprehend the transmission of COVID-19 and the improvement of air quality, we have studied air quality indicators (PM2.5, PM10, AQI, and NO2), CO2 emission, and climate variables (temperature, relative humidity, rainfall, and wind velocity) in the extremely polluted and densely populated Southeast Asian megacity Dhaka, Bangladesh from March to June 2020. The Kendall and Spearman correlations were chosen to test the connotation of air quality and climate variables with COVID-19 morbidity and mortality. The average concentrations of PM2.5, PM10, and CO2 were 65.0 with STD of 37.9 and 87.1 with STD of 52.8 microgram m-3, and 427 with STD of 11.8 ppm, respectively. The average PM2.5 and PM10 drastically reduced up to 62% during COVID-19 lockdown in Dhaka comparing with March 2020 (before lockdown). Comparing with the same period in 2019, PM2.5 reduced up to 33.5%. The average NO2 concentration was 35.0 micromol m-2 during the lockdown period in April, whereas 175.0 micromol m-2 during March (before lockdown). A significant correlation was observed between COVID-19 cases and air quality indicators. A strong correlation was obtained between climate variables and the total number of COVID-19 morbidity and mortality representing a favorable condition for spreading the virus. Our study will be very expedient for policymakers to establish a mechanism for air pollution mitigation based on scientific substantiation, and also will be an essential reference for the advance research to improve urban air quality and the transmission of the SARS-CoV-2 virus in the tropical nations.

Fabry disease is a rare X-linked recessive inborn error of metabolism due to deficient activity of the lysosomal enzyme, a-galactosidase A (a-Gal A). This results in the tissue accumulation of uncleaved glycosphingolipids within vascular endothelial lysosomes of various organs including skin, heart, kidneys and brain. We report a case of Fabry disease, in an 18-year-old boy, who presented with unilateral leg swelling and angiokeratoma corporis diffusum. Birdem Med J 2021; 11(2): 145-147