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Introduction:This study compared the antifungal effect of Zataria multiflora essential oil (EO) with that of sodium hypochlorite (NaOCl) as an irrigant for root canals infected with Candida albicans.Materials and Methods:Sixty mandibular premolars were infected with C. albicans suspension. After 72 h of incubation, the samples were divided into four groups. Teeth in Group 1 were irrigated with minimum fungicidal concentration (MFC) of Z. multiflora EO, in Group 2 with twice the MFC of Z. multiflora, in Group 3 with MFC of NaOCl, and in Group 4 with distilled water (DW). Pre- and post-operative samples were cultured, and fungal colony count of each specimen was obtained. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests (P < 0.05).Results:NaOCl at MFC and Z. multiflora EO at twice the MFC showed the highest antifungal efficacy, with no significant difference (P > 0.05). However, antifungal efficacies of these irrigants were significantly different from those of Z. multiflora EO at MFC and DW (P < 0.05).Conclusion:Our results showed that Z. multiflora EO at twice the MFC had the same antifungal efficacy as NaOCl at MFC.

The purpose of this study was to evaluate the disinfection of dentinal tubules with diclofenac sodium (DS), N‐acetylcysteine (NAC) and calcium hydroxide (CH). Contaminated dentinal blocks were divided into two control and seven experimental groups (n = 15): CH, DS, NAC, CH + 5% DS, 50% CH + 50% DS, CH + 5% NAC and 50% CH + 50% NAC. After seven days, dentine debris was obtained from two depths of 100 and 200 µm. The bacterial load was assessed by counting the number of colony‐forming units (CFUs). Pure DS exhibited maximum antibacterial activity at both depths. At 200 µm, it showed statistically significant differences with all the other groups (P < 0.05). Mixing CH with either 5% or 50% of DS and NAC did not increase the antibacterial efficacy (P > 0.05). Pure DS was most effective in disinfecting dentinal tubules, and mixing CH with DS or NAC is not recommended.

Background: Triple antibiotic pastes (TAP) has gained popularity as a root canal medicament in regenerative endodontic procedures and other endodontic treatment modalities. As this medicament changes the chemical structure of dentine, it may affect the bond strength of endodontic sealers to radicular dentine. This study aimed to evaluate the effect of TAP on the bond Strength of epoxy and methacrylate resin- based sealers to root canal dentine.Methods: In this in vitro study, eighty single-rooted human mandibular premolars were prepared using ProTaper rotary system. The specimens were randomly divided into a control group (without intracanal dressing) and an experimental group receiving TAP (n = 40). The intracanal dressing was removed after three weeks. Then samples of each group were randomly divided into four subgroups (n = 10) and obturated with gutta-percha and different resin-based sealers. G1: AH Plus, G2: Syntex, G3: EndoREZ, G4: MetaSEAL. After one week, 16 Slices of 1±0.1 mm thickness were obtained from the midroots of teeth in each subgroup and a push-out test was used to measure the bond strength. Slices were examined using a stereomicroscope at 30× to determine the mode of failure. The data were analyzed using two-way analysis of variance, one- way analysis of variance and Tukey post hoc tests (α = 0.05).Results: Compared to control group, TAP significantly increased the bond strength of MetaSeal and EndoREZ (p<0.05). In the control group, epoxy resin- based sealers showed higher bond strength compared to methacrylate ones (p=0.00). In TAP group, Syntex and EndoREZ showed significantly the greatest and the lowest bond strengths respectively (p<.05). The analysis of failure modes revealed a predominance of mixed failures in all groups except for Syntex group in which most failures were cohesive.Conclusions: TAP significantly increased the bond strength of methacrylate resin- based sealers.

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