The developed RP-HPLC technique lets in speedy and particular omeprazole and domperidone determinations, the goal of the current painting is to improve and extend the chromatographic circumstances, to broaden RP-HPLC method. a variety of mobility phases were tested for the duration of technique improvement, some of the numerous cell phases methanol, acetonitrile and phosphate buffer changed into discovered to be a perfect cell phase, because it provided optimal peak forms and high resolution. The go with the flow rate changed into optimized at 0.90 mL/min. The development of the isocratic elution method for omeprazole and domperidone made it perfect for quick and routine analysis. Omeprazole and domperidone linearity and correlation coefficient had been located to be 10 to 50 ug/mL 0.997, and 0.998, respectively. The restriction of detection for omeprazole and domperidone turned into discovered to be 1.78 and 3.15 and the limit of quantification changed into observed to be 544 and 956. With the assay procedure, the methodology has been recognized as accurate. The %assay become determined to be 98 and 73. The evolved technique changed into confirmed to an excellent accuracy and precision. The isocratic elution approach evolved for the dedication of omeprazole and domperidone perfectly suited for rapid and ordinary evaluation. This technique shows that right reproducibility of the effects. moreover this approach become easy, touchy, and accurate. Degradation studies had been accomplished, right here the drug stability outcomes have been within the variety of acceptance standards 85 to 115%. Moreover, this approach was easy, touchy, and correct.

Carvedilol and ivabradine is a drug combination used to treat cardiovascular diseases like hypertension, chronic stable angina pectoris and, chronic heart failure. Both are different in their mode of action. Carvedilol prevents exercise-induced tachycardia via inhibition of beta-adrenoreceptor carvedilol also acting on alpha-1 adrenergic receptors and an overall reduction in blood pressure. In case of a higher dose also shows antioxidant and calcium channel blocking activity. Ivabradine is a heart rate reducing drug that works by blocking cardiac pacemaker currents (If) selectively and specifically. The major goal of this review paper is to emphasize the characteristics of carvedilol and ivabradine, such as their pharmacological profiles, mechanisms of action, pharmacokinetic and pharmacodynamic studies, and previously described analytical methodologies for carvedilol and ivabradine determination. Various methods such as UV spectroscopy HPLC, RP-HPLC, UPLC. This review deals with the various analytical method reported and adopted for the estimation of carvedilol and ivabradine.

Carvedilol and ivabradine is a drug combination used to treat cardiovascular diseases like hypertension, chronic stable angina pectoris and, chronic heart failure. Both are different in their mode of action. Carvedilol prevents exercise-induced tachycardia via inhibition of beta-adrenoreceptor carvedilol, which also acts on alpha-1 adrenergic receptors and reduces blood pressure. In case of a higher dose also shows antioxidant and calcium channel blocking activity. Ivabradine is a heart rate-reducing drug that works by blocking cardiac pacemaker currents (If) selectively and specifically. The major goal of this review paper is to emphasize the characteristics of carvedilol and ivabradine, such as their pharmacological profiles, mechanisms of action, pharmacokinetic and pharmacodynamic studies, and previously described analytical methodologies for carvedilol and ivabradine determination. Various methods such as UV spectroscopy High-performance liquid chromatography (HPLC), Reverse phase -High performance liquid chromatography (RP-HPLC), Ultra-performance liquid chromatography (UPLC), Mass Spectrometry (MS), High-performance thin layer chromatography (HPTLC). is the most accurate easy method for estimation.