Background: Warts are one of the most common benign growths in the dermatological outpatient department but are many times tough to treat as they are chronic, resistant, and relapsing to available treatment. A variety of therapeutic modalities have been used with varying degree of success. However, till date, no therapeutic modality had been fully successful. Aim and Objectives: The present study was conducted to evaluate the therapeutic efficacy and safety of intralesional (IL) bleomycin injection in common warts. Materials and Methods: A total of 50 patients of common warts were enrolled in this evaluator blinded randomized placebo-controlled study. Group A consists of patients to be treated with IL bleomycin, and Group B consists of patients to be treated with IL normal saline. A total of 25 patients were enrolled in each group. Patients of both groups were asked to follow-up after 4 weeks for maximum of 4 times, i.e. at 8 weeks, 12 weeks, at the end of 6 months as a final visit, and assessed clinically every time. Results: Out of 87 wart lesions in Group A patients, 81 (93.10%) showed a complete resolution. A progressive clearance of the warts was seen, after the first injection (64%) and second injection (36%), only 6 warty growths (7%) were nonresponders to treatment. However, in Group B, only 4 (5%) showed disappearance within 12 weeks and even after 6 months of follow-up (P < 0.05 by × 2 analysis and risk ratio = 7.67). Conclusion: IL bleomycin injection was significantly safer and effective, with better patient acceptance in treating common warts.

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Familial poikiloderma-like cutaneous amyloidosis(FPLCA) is a rare, generalized but genetic dyschromic skin disorder characterized by amyloid deposits in dermis due to defective DNA repair secondary to sunlight damage. Clinically, it presents with diffuse brownish pigmentation with hypo-pigmented macules and many brownish scattered lichenoid papules with normal developmental milestones. The condition is autosomal dominant with incomplete penetrance. We are here reporting a rare familial case of FPLCA with a review of the literature

Disseminated superficial actinic porokeratosis (DSAP) is the most common of the porokeratoses. DSAP tends to be inherited as an autosomal dominant disorder, with the earliest reported age of onset at 7 years, and is usually fully penetrant by the third or fourth decade of life but sporadic cases are also seen. It is more frequent in females and the pathogenesis remains unknown. Lesions are characteristically uniformly small, annular, asymptomatic, or mildly pruritic papules ranging from 2 to 5 mm in diameter, distributed symmetrically on the extremities. Lesions are more generalised than other forms of porokeratosis located predominantly on the sun-exposed sites. On histological examination, cornoid lamella is characteristic. We report on a case of DSAP in a 21-year-old female who presented with multiple asymptomatic skin lesions over upper extremities, face, neck and upper back since 2 years. On histopathological examination, hyperkeratosis, parakeratosis, cornoid lamella is seen. Granular layer was thinned out below cornoid lamella and nonspecific dermal inflammatory infiltrate is seen.

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