Background: Cicatricial alopecia is a group of disorders that destroy hair follicles which are replaced with fibrosis, causing permanent hair loss. Cicatricial alopecias are subdivided into two groups "primary" and "secondary". For management of 2ry cases, there are different strategies which differ with the location, size and other scarred area characteristics. These strategies include certain surgical procedures such as excision, flap surgery, use of tissue expansion, and hair transplantation that gained popularity as a permanent method for restoring hair loss. In cicatricial alopecia cases, hair transplant is considered challenging because of the degenerative changes and decreased vascularity of these areas that may produce a lower survival rate of donor hair. Aim of Study:This study aimed to evaluate the role of PRP and nanofat injections together with follicular unit extraction technique in restoration of hair in secondary cicatricial alopecia.Material and Methods: This study was conducted on 30 patients with secondary cicatricial alopecia. Patients were divided into 3 groups, 10 patients in each. Group A: Received PRP with hair transplantation, group B: Received nanofat injections with hair transplantation, while in group C (Control group) patients underwent hair transplantation only.Results: Although adding PRP or nanofat injections with hair transplantation procedure provides an excellent improvement in the texture and quality of the scarred tissues compared to other cases underwent without, there were no significant differences in the clinical outcomes of hair restoration including hair growth density.
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